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SlimonaTM For Whom?

SlimonaTM is a prescription drug used to treat overweight people with initial BMI of  >= 30 Kg/m2  or overweight people with BMI of 27 or higher with medical risk factors like high BP, diabetes and high cholesterol.

SlimonaTM (Rimonabant) is prescribed to aid weight loss in overweight people with initial BMI of  >= 30 Kg/m2  or overweight people with BMI of 27 or higher with medical risk factors like high BP, diabetes and high cholesterol. It should be used in combination with a reduced calorie diet and an exercise programme.

Dosage

SlimonaTM is to be taken only after the advice of your doctor. SlimonaTM tablet should be taken once a day, in the morning before breakfast. Do not take dosage more than your doctor has prescribed.

It is important to continue to follow a diet and an exercise programme during and after treatment with this medicine to help you maintain any weight loss.

 
Safety Information

SlimonaTM is a prescription drug used to treat overweight people with initial BMI of  >= 30 Kg/m2  or overweight people with BMI of 27 or higher with medical risk factors like high BP, diabetes and high cholesterol.

The following are some of the side effects that are known to be associated with this medicine.

  • Nausea , Vomiting, Dizziness , Stomach Upset , Muscle cramps, Mood Changes

These side effects are usually mild and fade away with continual usage of this medication. In case, you experience these or any other side effects for a prolonged span of time, consult your doctor immediately.

Pregnant women and Breast-feeding mothers should abstain from consuming SlimonaTM (Rimonabant). Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

SlimonaTM (Rimonabant) is not recommended for children and adolescents under 18 years of age, because its safety and efficacy have not been studied in this age group.

This medicine should not be used in patients with severely decreased liver function, severely decreased kidney function, uncontrolled serious psychiatric illness and uncontrolled depression.

The safety and efficacy of this medicine when used for longer than two years have not yet been studied.

SlimonaTM should not be used if you are allergic to one or any of its ingredients. Please inform your doctor if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor immediately

It is important to tell your doctor which medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor before taking any new medicines while taking this one, to ensure that the combination is safe.

For more information about any other possible risks associated with this medicine, please consult your doctor

 
Frequently Asked Questions

What is Excessive Weight?

Excessive Weight can be simply defined as an excess of body fat. Excessive Weight is an excess accumulation of fat in the body to such a serious degree that it rapidly increases the risk of Excessive Weight-associated diseases and mortality (death).

 

What are the methods to assess Excessive Weight?

Excessive Weight is usually diagnosed on the basis of calculation of
Body mass index
Measurement of waist-hip ratio

Body Mass Index (BMI)

One of the most widely accepted means of assessing Excessive Weight and overweight is the Body Mass Index (BMI). It is calculated as your weight (in kg) divided by your height (in meters) squared.
People with BMI between 18.5 and 25 (kg/m2), are considered as having normal weight and people with a BMI of 25 to 30 (kg/m2) are considered overweight, while people with a BMI over 30 (kg/m2) are considered excessive weight.

Waist and Hip Measurements
Waist and hip measurements are useful for defining body fat distribution, which is of special value when assessing health risks.

Waist circumference
Waist circumference is the simplest method for identifying the need for weight management. A study has identified waist circumference as a simple predictor of health risks.

Waist circumference of 94-102 cm in men and 80-88cm in women is considered as over weight and waist measurement of >102cm in men and >88cm in women is considered as Excessive Weight.

Waist to hip ratio (WHR)

WHR is waist circumference divided by hip circumference. Risk increases if a ratio of 1.0 or greater in men, and greater than 0.8 in women

What is the cause for Excessive Weight?

Excessive Weight is caused by an imbalance in energy intake and energy expenditure. Excessive Weight develops from overeating and lack of daily physical activity. Excessive Weight can be hereditary; hence some people are at increased risk. Many people think that when a disease is hereditary, it is inevitable that one would suffer from the condition but this is not true. If people take right food and does proper physical activity, then only a few of them would be overweight or excessive weight. It is lifestyle, which determines. In addition to food, physical activity and genes, it is possible that other, so far unknown elements may play a part.

 

What is apple-shaped body and pear-shaped body?

The distribution of fat around the waist is known as ´apple-shaped´ body and the distribution of fat around the buttocks and thighs is ´pear-shaped´ body. Apple-shaped body has a higher risk of morbidity and mortality due to heart and blood vessel diseases than the pear-shaped body.

 

When should one reduce weight?

With BMI of more than 25, it is advisable to change lifestyle and reduce body weight, especially if it is an abdominal Excessive Weight (apple-shaped). Men with a waist circumference of more than 94cm and women with a waist circumference of more than 80cm should not further increase their weight. An increased risk of Excessive Weight-related diseases is present with a waist circumference of more than 102cm for men and more than 88cm for women. If your BMI is more than 30, it is required to reduce your weight.

 

What are the serious Excessive Weight-related diseases?

People with Excessive Weight more frequently have high blood pressure and diseases related to hardening of the arteries, with blood clots in the heart and the brain. Other related problems include non-insulin dependent diabetes, gallstones, and some types of cancer, difficulties in mobility and increased risk of mortality.

In addition, being overweight and excessive weight may cause several psychosomatic problems like feeling of inferiority often caused by discrimination. Additionally, many physical problems are related to Excessive Weight, like, personal hygiene, knee joint pain, back pain, skin problems and breathing difficulties.

 

What are the options available for Excessive Weight treatment?

A variety of effective options exist for the management of overweight and excessive weight patients, including dietary therapy approach such as low-calorie diet and low-fat diet; altering physical activity patterns; behavior therapy techniques; drug therapy; surgery and combinations of all these techniques.

 

What are the benefits of reducing weight?

A weight loss of 5 or 10 kg has a very positive effect on the risk of heart and blood vessel diseases. The weight loss will not only reduce blood pressure and blood-cholesterol, but also have a beneficial impact on Excessive Weight-related diseases. It is reported that weight loss of 0.5-9 kg has been associated with 53% reduction in cardiac -deaths, 44% reduction in diabetes-associated mortality and 20% reduction in total mortality.

 

When is drug treatment necessary?

Obviously, not everybody needs drug therapy. If excessive weight patients reduce weight by diet and exercise and are able to maintain their weight, there is no need for drug treatment.

However drug treatment is necessary for those with a BMI of more than 30 who have not reduced weight by diet changes, exercise or lifestyle changes and those with BMI of more than 27 and the presence of risk elements or complications. It is also required for those with BMI of more than 27 who have experienced a previous rapid increase of weight.

How to maintain weight after weight reduction?

Weight loss is obtained most effectively by proper diet therapy and altering physical activities. However, by far the greater challenge is achieving a way of life that maintains the weight and reduces the chances of putting on it back.

Drug treatment may be necessary in some patients to prevent them from regaining the weight.

 
Exercise

For obesity treatment, exercise has been established as an effective option.

Primarily, the research focuses on two strategies:

(1) Exercise for weight reduction, with the premise that lower body weight can lead to better health.
(2) Exercise for health and fitness, with the philosophy that correct exercise can lead to better health, no matter what the resulting weight change.

In all circumstances of exercise intervention, consultation with a physician should be done first to rule out any contraindications to exercise.

Exercise for Weight Loss

In order to loose weight an energy deficit must be met.
Essentially, this means that throughout the day and individual must burn (expend) more calories than they consume (absorb) from food. Many attempt to loose weight by dietary modification alone. This, when done appropriately can garner positive results However, many individuals that modify their diet do so inappropriately by either not getting enough calories or choosing diets that lack proper nutrients and balance. The term, yo-yo dieting, is often used to describe the up-and-down weight fluctuations that can occur with drastic dietary plans. Some studies have implied that weight fluctuations may be more harmful than remaining overweight.

Diet alone is seldom recommended by doctors for weight reduction One reason for this is that diet without exercise does not improve cardio respiratory fitness

If the goal is to loose weight, the combination of energy intake reductions and energy expenditure increases through structured exercise and other forms of physical activity are recommended as a weight loss intervention.

Exercise can be a key component for inducing an energy deficit.
When an individual exercises, they expend more calories then when sedentary.
Research has demonstrated that structured exercise interventions alone can produce weight loss as well as changes in body composition.

The American College of Sports Medicine (ACSM) recommendations for weight loss programs as follows:

  • A cardiovascular exercise program of a minimum of 3 days per week, 20 - 30 minutes per session. Ideally, a 5 day per week 30 minute per session (or 150 minutes of cumulative exercise per week) should be performed. Additionally, there may be additional benefits in progressively increasing exercise to 200 - 300 (3.3 - 5 h) per week. The program should be at a minimum of 60% HRmax in otherwise healthy individuals.
  • Additionally, strength training may provide benefit through the development of lean muscle mass.
  • A diet that provides a minimum of 1200 calories per day for normal adults to meet nutritional requirements.
  • The diet should include food that is acceptable to the individual in terms of nutritional needs, sociocultural background, taste, cost, and ease of acquisition and preparation.
  • The difference between energy intake and expenditure should provide a negative caloric balance that does not exceed 500 - 1000 calories per day and results in gradual weight loss without metabolic abnormalities. Weight loss should not exceed 2.2 lb per week.
  • Behavior modification should be instigated in order to identify and eliminate dieting habits that contribute to improper nutrition.
  • New eating and physical habits should be reasonable, manageable, and appropriate. This is important if such habits are expected to be continued for life.

Exercise for Health and Fitness

Recent research has explored the effects of cardiorespiratory fitness on men of various BMI's and body compositions. What such studies have found is that the health benefits of being lean are limited to those who are physically fit.

Recent research has come to following conclusion.

  • Unfit lean men have double the mortality risk of fit lean men.
  • Unfit lean men have a higher risk mortality and cardiovascular disease than men who are fit and obese.
  • Unfit men have a higher risk of mortality and cardiovascular disease than fit men in all categories of fat and fat-free mass.
  • Unfit men with low waist girths have a higher risk of mortality than fit men with high waist girths.
  • Being obese does not appear to increase mortality risk in fit men.

Such findings indicate that obese men should be encouraged to increase their cardiorespiratory fitness through regular, moderate intensity physical activity.

Benefits should be achieved even if they remain overweight.

The American College of Sports Medicine (ACSM): Specific recommendations for Exercise Program :

Cardiorespiratory Fitness and Body Composition Guidelines

  • Frequency of training sessions: 3 - 5 days per week. This does not mean one cannot or should not choose some form of physical activity on non-training session days. Examples: gardening and yard work, walking the dog, etc.
  • Intensity of training: 65 - 90% of maximum heart rate (HRmax) or 55 - 64% HRmax for those that are especially unfit.
  • Duration of training: 20 - 60 minutes of continuous or intermittent (minimum of 10-min bouts accumulated throughout the day) aerobic activity. Duration is dependent on intensity, therefore, lower intensity activities should be conducted over longer time periods (? 30 minutes) and higher levels of activity should be maintained for 20 minutes or longer. Moderate intensity over longer duration is recommended for adults not training for athletic competition.
  • Mode of activity: activities that use large muscle groups and can be maintained continuously. Such modes of activity should be rhythmical and aerobic in nature. Examples: walking, hiking, running/jogging, cycling, cross-country skiing, aerobic dance/group exercise.

Muscular Strength and Endurance, Body Composition, and Flexibility Guidelines.

  • Resistance training sessions:
    Frequency of training: 2 - 3 days per week
    Sets and Repetitions: Multiple-set regimens may provide greater benefit if time allows. Most people should complete 8 - 12 repetitions of each exercise. It may be appropriate for frail individuals to complete 10 - 15 repetitions at a lower relative weight.
    Resistance training should be progressive, individualized, and provide stimulus to all major muscle groups.
  • Flexibility training sessions: Flexibility exercises should stretch the major muscle groups and be performed a minimum of 2 - 3 days per week and should incorporate appropriate static (held 10 - 30 sec) and/or dynamic techniques. The rational behind flexibility training is to develop and maintain range of motion (ROM).

Type of Exercise based on oxygen consumption:

Depending of the oxygen consumption, exercise is can be classified as aerobic or anaerobic. The  terms "aerobic" and "anaerobic" refer to the presence and absence of oxygen, respectively.

Most cells of our body prefer to get the energy they need by using oxygen to fuel metabolism. During exercise with adequate fuel and oxygen ( i.e., aerobic), muscle cells can contract repeatedly without fatigue.

During anaerobic or non-oxygen conditions (higher intensity exercise), muscle cells must rely on other reactions that do not require oxygen to fuel muscle contraction.
This anaerobic cell metabolism produces waste molecules that can impair repeated muscle contractions. We call this deterioration in performance as fatigue.

While at rest, we rely totally on aerobic metabolism to fuel almost all our body's needs for energy. As we start to exercise, such as progressing from sitting to a slow walk, the increased energy needs of muscle contraction require that we increase our breathing and oxygen intake.
So long as we increase our exercise intensity slowly, we can maintain our muscle's dependence on aerobic metabolism, and we don't experience symptoms of fatigue.

However, as exercise intensity increases, the need for energy release eventually exceeds that which can be supplied by aerobic metabolism.
Our muscles simply need more reactions to support the energy demand.
Therefore, anaerobic contribution to metabolism increases.
When this happens, we refer to this change in metabolism as a metabolic threshold.
This metabolic threshold represents the exercise intensity where we start to produce those waste products of anaerobic metabolism that can eventually lead to fatigue.

Aerobic exercise conditions enable you to exercise for long periods of time, potentially benefiting from the sustained energy expenditure (i.e., calories burned). Aerobic exercise tends to be less stressful to muscles, joints, and your heart, which may be important for individuals with arthritis, heart disease, or high blood pressure. However, to more rapidly improve your exercise capacities, tolerance, and performance, some anaerobic exercise training is a necessity.

Therefore, performing anaerobic exercise is typically more suitable for competitive athletes and less so for weight reduction programs.

Metabolic equivalent

A unit of metabolic equivalent, or MET, is defined as the number of calories consumed by an organism per minute in an activity relative to the Basal metabolic rate (BMR/RMR, see below). A single unit (1 MET) is the caloric consumption of that organism, or individual, while at complete rest. For example, one might consider the restful state following a quiet night's sleep as a good example of a single MET. This is a base-line unit for that one individual, and since each individual has a varying BMR, a MET is, therefore, variable from one person to the next. One might consider a single unit the energy required to just stay alive without doing anything more.

The unit is commonly used in the context of aerobic exercise to gauge the intensity of the workout. A workout of 2-4 METs is considered light, while intensive running (8 minutes/mile, or 12 km/h) or climbing can yield workouts of 12 or more METs.

Since METs are variable units, they can only be used in calculating relative energy expenditures in "context;" meaning within the parameters per individual, unlike caloric expenditures which are unitary standards not variable from one person to another. While exercising at 6 METs, a 200-pound (90 kg) man would burn considerably more calories than his 120-pound (55 kg) son doing the same exercise.

METs are particularly relevant to those who intend to lose weight, because they are a simple approximation of the rate at which exercise causes calories to be burned. Many modern exercise machines can indicate METs, although the numbers given are estimates since, as mentioned above, the rate at which calories are burned while at rest (the Basal Metabolic Rate or, more strictly, the Resting metabolic rate: RMR) varies from person to person.

The Types of Exercise based on muscle contraction.

One type of classification of exercise is based on type of muscle contractions.
There are four different types of muscle contraction.
1. Isotonic
2. Eccentric
3. Isometric
4. Isokinetic

Isotonic

All lifting exercises require Isotonic contractions. This happens when the muscle shortens as it contracts. Typical examples are lifting objects above the head - front shoulder (anterior deltoid) shortens, doing a sit up, throwing a ball

In fact Isotonic contractions are the most common, many exercises and activities we routinely do involve this type of contraction.

Eccentric

Eccentric contraction is the opposite of isotonic, the muscle lengthens as it gains tension. These are much less common and not as beneficial as the common Isotonic. An example is when someone manages to pull your arm straight while at the same time you are try to keep the arm locked in one position. In other words, the load is too great!

Other examples are...
running downhill
walking downstairs
landing on the ground from a jump
This type of contraction is not recommended!

Isometric

An Isometric contraction happens when there is tension on the muscle but no movement is made causing the length of the muscle to remain the same. This type of contraction is also referred to as a static contraction. Typical example include attempting to lift an immoveable object, or some wrestling movements.

These type of exercises are generally not suitable for weight reduction programs.

Isokinetic

Similar to the Isotonic contraction, the Isokinetic contraction causes the muscle to shorten as it gains tension. The difference is Isokinetic requires a constant speed over the entire range of motion, therefore this type of contraction require special equipment to exercise properly. An example is an arm stroke when swimming, the even resistance from the water offers a constant speed.

As far as weight reduction goal is concerned isotonic and isokinetic exercises gives similar benefits.

While exercising our muscles burn both fat and glucose (carbohydrates in the blood) in different proportions. Depending on how an individual exercises muscle can burn fat in a larger proportion to glucose.

When activity is light and easy we tend to burn a much higher percentage of fat. Fat is a slow burning fuel that requires oxygen so if oxygen is delivered to muscle cells in sufficient quantities the cells can easily burn fat for most of its energy requirement. A potential problem for weight loss is lighter exercise burns fewer total calories.

If an individual increases their effort by performing a more intense exercise they will burn more calories however, because oxygen cannot always be delivered to the hard-working cells in sufficient quantities, cells are forced to burn more carbohydrates in order to keep up with increasing demand. If the level of exertion continues to increase then glucose eventually becomes the predominant energy source for muscles as this quick-burning fuel does not require oxygen. It means to burn fat directly we should exercise at a lower level of effort and for longer duration.

The best way to exercise will depend on whether you want fat burning, fitness or muscle toning. The way we choose to exercise determines the results and which fuel the working cells use, for example, a more aggressive way of exercising will result in the use of carbohydrates as the main source of energy and will even stress the muscles enough to cause the toning or building up of muscle. A more gentle way of exercising means the cells can best use the slow-burning fuel - fat!

Time may also come into the equation, the best way to exercise for effective fat burning is at a low intensity for at least 30 minutes. However, for increased fitness it requires a moderate level of effort but performed for 15 minutes.

As can be seen there are different ways to exercise in order to gain