Available Dosages
| SKU: | 36 |
|---|---|
| Generic For: | Norvasc Tenormin |
| Active Ingredient: | Amlodipine Besilate + Atenolol |
| Manufacturer: | Cipla, India |
Buy Amlopres AT 5 +50mg (Amlodipine Besilate + Atenolol) Online
Amplopres AT is a combination drug consisting of Amlodipine Besylate and Atenolol. Amlodipine Besylate is a calcium channel blocker and is used in hypertension and prevents chest pain while Atenolol is a beta-blocker widely employed in hypertension, chest pain and post-heart attack. A fixed-dose combination of both the drugs produces enhanced anti-hypertensive effects. This dual combination is one of the most preferred antihypertensive drugs as it has excellent patient compliance and safety profile. Amlodipine Besylate and Atenolol are given in hypertension, chest pain and heart attack.
Amlodipine Besylate is a calcium channel blocker as it stops the influx of calcium ions through L type calcium channels. By inhibiting the entry of calcium channels, one can decrease the contractility of arterial smooth muscles and causes vasodilation. This all leads to relaxation of blood vessels and aids smooth arterial blood flow. In this way, it reduces the overall elevated blood pressure.
Atenolol binds with beta receptors present in the heart and vascular smooth muscles. It relaxes the blood vessels and lowers the blood pressure. It provides sufficient oxygen to the heart and other tissues. It helps in regulating proper heartbeat, therefore useful in a heart attack.
Limit the intake of alcoholic beverages and avoid activity that requires alertness as it causes dizziness. Monitor your blood pressure levels regularly. Excess sweating, vomiting and diarrhoea causes loss of water in excess and increases the risk of light-headedness. Always compensate for the fluid loss or dehydration with drinking loads of water.
Always inform your doctor about the drugs you are taking till date. This way, the doctor can decide and give you the list of drugs and other things that may interact with Amlodipine Besylate and Atenolol. Medicines that can interact with Amlopres AT are cocaine, diabetes medicine, grapefruit juice, phenobarbital, other hypertensive drugs, calcium, NSAID’s, rifampin, zafirlukast, clarithromycin, amiodarone, fluoxetine, medications for prostate problems etc.
All medicines have their side effects, sometimes they are serious, but most of the times they are not. Common side effects include dizziness, facial flushing, anxiety, fatigue, dry and itchy skin, unexplained tiredness or weakness, abdominal pain, flatulence, headache, insomnia, and lightheadedness.
Always take the dose as prescribed by the physician. It is very important to consume medicine timely. The general recommended dose starts from one tablet of Amlodipine 5mg/ Atenolol 50 mg and can be increased depending upon the patient’s condition and demand. With time, dose adjustments are generally done according to the response of the patient. Always take medicine as prescribed by the doctor. You must swallow the whole tablet with one glass full of water. Do not crush or chew it. Amlodipine Besylate and Atenolol is taken once daily with or without food. It is the best way to take medicine at the same time daily because it shows the best results and helps to remember when to take the drug. It is important to take the medication as instructed by your doctor. Abrupt discontinuation of medicine can cause adverse reactions. So before stopping the drug intake, always consult a physician.
What is Amlopres AT 5+50mg used for?
Amlopres AT 5+50mg is a fixed-dose combination tablet containing amlodipine 5mg (a dihydropyridine calcium channel blocker) and atenolol 50mg (a cardioselective beta-1 blocker). It is prescribed for hypertension that requires dual antihypertensive therapy, and for patients with concurrent stable angina where both agents offer synergistic benefit — amlodipine dilates coronary arteries and reduces peripheral resistance, while atenolol reduces heart rate and myocardial oxygen demand. The combination provides complementary cardiovascular protection: amlodipine reduces arterial blood pressure; atenolol reduces cardiac output and blunts the reflex tachycardia that amlodipine can occasionally trigger, making this a particularly effective pairing.
How do amlodipine and atenolol work together in Amlopres AT 5+50mg?
Amlopres AT 5+50mg combines amlodipine and atenolol to control high blood pressure through two different actions. Amlodipine relaxes and widens the blood vessels, improving blood flow and lowering pressure in the arteries. Atenolol slows the heart rate and reduces the force with which the heart pumps blood, decreasing the heart’s workload. Together, these medicines provide more effective blood pressure control and may also help reduce chest pain and the risk of heart-related complications when used regularly as prescribed.
What is the dosing schedule for Amlopres AT 5+50mg?
Amlopres AT 5+50mg is taken once daily, at the same time each day, with or without food. The fixed-dose tablet should be swallowed whole. Once-daily dosing is possible because amlodipine has a very long half-life (35–50 hours) and atenolol has a moderate half-life (6–9 hours) with sufficient duration at 50mg to maintain 24-hour beta-blockade. Blood pressure and heart rate should be checked 2–4 weeks after starting to assess response. Do not stop atenolol abruptly — beta-blocker withdrawal can cause rebound hypertension, angina, or even MI in patients with coronary artery disease. If stopping is needed, the dose should be tapered gradually over 1–2 weeks under physician guidance.
Is Amlopres AT 5+50mg suitable for patients with angina?
Yes. Amlopres AT 5+50mg is particularly well suited for patients with concurrent hypertension and stable angina pectoris. Both components have antianginal properties through complementary mechanisms: amlodipine dilates epicardial coronary arteries (including vasospastic angina), reduces afterload, and improves coronary blood supply; atenolol reduces heart rate and myocardial oxygen demand, limiting angina triggers. This combination is effective across both effort-induced (classic) and mixed angina. The dual antianginal mechanism makes Amlopres AT more effective for angina symptom control than either agent alone. In patients with hypertension plus stable angina, using a single combination tablet reduces pill burden and improves adherence.
Can Amlopres AT 5+50mg be used in patients with asthma?
Amlopres AT 5+50mg should be used with caution or avoided in patients with asthma or significant COPD. Although atenolol is a cardioselective (beta-1 selective) beta-blocker, cardioselectivity is dose-dependent and partial — at 50mg, beta-2 blockade in bronchial smooth muscle can still occur to a clinically relevant degree, potentially causing or worsening bronchoconstriction in asthmatic patients. Amlodipine alone (without atenolol) is safe in asthma. For hypertensive asthmatic patients who also have angina, alternatives to atenolol-containing combinations should be discussed with the physician — such as amlodipine + a long-acting nitrate or amlodipine + ivabradine for rate control in angina.
What precautions apply to Amlopres AT 5+50mg?
Precautions for Amlopres AT 5+50mg include: never stop atenolol abruptly (rebound hypertension and angina risk — always taper); avoid in patients with asthma, significant COPD, second or third degree heart block, severe bradycardia, or decompensated heart failure; monitor heart rate — keep resting rate above 50–55 m; monitor blood pressure at rest and on standing for orthostatic hypotension; avoid concurrent verapamil or diltiazem (increased bradycardia and heart block risk); atenolol masks hypoglycaemia symptoms in insulin-dependent diabetics (except sweating); inform surgeon before any planned surgery that you are on a beta-blocker; check renal function — atenolol is renally excreted and dose adjustment may be needed in CKD.
How does Amlopres AT compare to taking amlodipine and atenolol separately?
Amlopres AT 5+50mg provides identical pharmacological benefit to taking amlodipine 5mg and atenolol 50mg as separate tablets — the fixed-dose combination delivers the same bioequivalent drug exposure. The key advantage is convenience: one tablet daily instead of two, improving adherence — particularly important in hypertension where long-term medication adherence directly determines cardiovascular outcomes. For patients already established on both agents at exactly these doses and who prefer a combined tablet for simplicity, Amlopres AT provides a practical and often more affordable option than two separate branded products. It is not suitable as initial antihypertensive therapy — both doses should be established separately first.
Is Amlopres AT 5+50mg better than amlodipine alone for blood pressure?
For patients with hypertension requiring only mild additional blood pressure reduction beyond what amlodipine 5mg provides, the addition of atenolol 50mg in Amlopres AT offers meaningful incremental benefit — typically 5–10 mmHg additional systolic reduction. Beyond blood pressure control, the combination provides superior protection against angina epiSodiumes in patients with coronary artery disease. However, for uncomplicated hypertension without concurrent angina, ischaemic heart disease, or indications for beta-blockade, current guidelines favour combining amlodipine with an ACE inhibitor or ARB (e.g., amlodipine + ramipril) over amlodipine + atenolol, as evidence shows superior cardiovascular event reduction with the ACE inhibitor-based combination (ASCOT trial).
Can I buy Amlopres AT 5+50mg from AllDayChemist?
Yes, Amlopres AT 5+50mg is available at AllDayChemist, a licensed pharmacy serving patients in the USA, UK, Australia, and most of the countries since 2002. AllDayChemist sources authentic amlodipine/atenolol combination tablets from licensed manufacturers at competitive prices. The combination tablet is particularly cost-effective compared to purchasing branded amlodipine (Norvasc) and atenolol (Tenormin) separately. AllDayChemist provides worldwide tracked delivery and discreet packaging. Atenolol is a prescription-only beta-blocker — confirm medical clearance, appropriate indication, and ongoing monitoring before ordering, and never stop the medication without physician guidance.
Does AllDayChemist ship Amlopres AT 5+50mg internationally?
Yes, AllDayChemist ships Amlopres AT 5+50mg to the USA, UK, Australia, and most of the countries globally. With over 20 years of operation since 2002, AllDayChemist provides reliable worldwide tracked delivery with discreet packaging for all orders. For patients managing hypertension and angina with long-term combination amlodipine/atenolol therapy, AllDayChemist offers a cost-effective international supply option. Check import regulations for prescription combination antihypertensives in your country before ordering — AllDayChemist's customer service team can provide guidance on delivery requirements for your specific region.
What are the side effects of Amlopres AT 5+50mg?
Side effects of Amlopres AT 5+50mg reflect both components. From amlodipine: peripheral oedema (ankle swelling — most common, 8–10% at 5mg), flushing, headache, and dizziness. From atenolol: fatigue and lethargy (the most common beta-blocker complaint), cold extremities, mild depression, bradycardia, and blunting of hypoglycaemia symptoms in diabetics. Both components together may cause orthostatic hypotension. Erectile dysfunction occurs with atenolol more than with amlodipine alone. Beta-blocker withdrawal rebound applies to atenolol — never stop the combination tablet abruptly. Atenolol reduces exercise tolerance at 50mg, which may be relevant for physically active patients. Monitor heart rate and blood pressure regularly during Amlopres AT therapy.
Does Amlopres AT 5+50mg cause fatigue?
Yes. Fatigue and lethargy are among the most commonly reported side effects of atenolol (the beta-blocker component in Amlopres AT 5+50mg). Atenolol reduces cardiac output and blunts the sympathetic nervous system's response to exercise and stress, which manifests as reduced exercise tolerance and general tiredness in some patients. This is a dose-related effect and more pronounced in physically active individuals. The amlodipine component does not cause fatigue. If fatigue is significant and limiting, the physician may consider reducing the atenolol dose, switching to a beta-blocker with more favourable tolerability (such as carvedilol or bisoprolol), or reviewing whether atenolol is the most appropriate drug for the specific indication being managed.
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