Arthrotec 75mg/200mcg
Out Of Stock
| SKU: | 319 |
|---|---|
| Active Ingredient: | Diclofenac Sodium - Misoprostol |
| Manufacturer: | Pharmacia, UK |
Buy Arthrotec 75mg/200mcg (Diclofenac Sodium - Misoprostol) Online
What is Diclofenac Sodium – Misoprostol?
Diclofenac Sodium – Misoprostol is a combination medicine of NSAID (non steroidal anti-inflammatory drug (Diclofenac Sodium)) and acid reducer (Misoprostol) that not only reduces inflammation and pain in the body but also reduces stomach acid and reinstates protective substances in the stomach that are destroyed by NSAIDs. This medication is primarily used to treat osteoarthritis and rheumatoid arthritis in people who are at a high risk of developing stomach or intestinal ulcers.
Diclofenac Sodium – Misoprostol gastro medication functions by lowering hormones that cause inflammation and pain in the body. It is sold under various trade names across the globe, one of which is Arthrotec (made by Pharmacia, UK). Diclofenac Sodium – Misoprostol may also be prescribed for conditions not mentioned here.
Important Information about Diclofenac Sodium – Misoprostol
Diclofenac Sodium – Misoprostol gastro medication (Arthrotec) is classified as a FDA pregnancy category X drug and hence, it is strictly not recommended during pregnancy. If taken while being pregnant, Misoprostol can result in premature labor, miscarriage, ruptured uterus, or birth defects. Diclofenac can also cause birth defects if taken in the last trimester of the pregnancy. Make sure to use a good contraceptive method. Notify your doctor immediately if you become pregnant while taking Diclofenac Sodium – Misoprostol medication. This medication can pass into breast milk and harm a nursing baby. Ask your doctor if it is safe for your baby and you to take this medication while you are breast feeding.
Diclofenac Sodium – Misoprostol usage may lead to life threatening heart or circulatory problems such as heart attack or stroke, especially if taken for a prolonged period. This medication is not recommended just before or after a heart bypass surgery. You must seek emergency medical attention if you have chest pain, weakness, shortness of breath, slurred speech, or difficulties in vision or balance after taking Diclofenac Sodium – Misoprostol.
Diclofenac Sodium – Misoprostol may also impact stomach or intestines severely by causing bleeding or perforation in them. Inform your doctor right away if you witness symptoms of stomach and intestinal bleeding such as stools which are black, bloody, or tarry in appearance; bloody cough or vomit that resembles coffee grounds. These effects can be dangerous and fatal and come up without any warning while you are on Diclofenac Sodium – Misoprostol treatment. The risk is high, especially in older adults. Avoid alcohol while taking this medication as alcohol can complicate the conditions and put you on a higher risk of bleeding.
Before taking Diclofenac Sodium – Misoprostol
Do not take Diclofenac Sodium – Misoprostol medication (Arthrotec) if you are allergic to any of its active ingredient that is Diclofenac Sodium or Misoprostol or if you have allergies towards other drugs like aspirin and other NSAIDs. Remember to take care of all precautions and points mentioned above before taking this medication. Discuss them with your doctor thoroughly.
To ensure safe use of Diclofenac Sodium – Misoprostol medication, let your doctor know in advance if you have any of these conditions: asthma; polyps in your nose; porphyria; bleeding or blood clotting disorder; if you smoke; if you have a history of heart attack, stroke, or blood clot; liver or kidney disease; heart disease, congestive heart failure, high blood pressure, or a history of stomach ulcers or bleeding.
How should I take Diclofenac Sodium – Misoprostol?
Take Diclofenac Sodium – Misoprostol gastro medication (Arthrotec) strictly according to your doctor’s direction or according to the instructions on the medication label. Do not alter the dosage unless your doctor advises you to do so. Also, do not take this medication after the prescribed period is over.
Take Diclofenac Sodium – Misoprostol tablet with a full glass of water and ensure that you swallow the table whole. Avoid crushing, breaking, or chewing the pill. Taking this medication with food will reduce the chances of stomach upset. Always store Diclofenac Sodium – Misoprostol medication in a cool and dry place.
What if I miss a dose?
If you miss a dose of Diclofenac Sodium – Misoprostol medication, take it as soon as you remember. Don’t take the missed dose if the time to take the next dose is almost up. Taking multiple doses near to each other can lead to excess medication in your body which can be harmful.
What if I overdose?
In case of an overdose of Diclofenac Sodium – Misoprostol, get emergency medical attention or call the Poison helpline at 1-800-222-1222. Overdose may lead to drowsiness, muscle weakness, nausea, vomiting, stomach pain, shortness of breath, light headedness, or fainting.
Things and Activities to avoid while taking Diclofenac Sodium – Misoprostol
Certain antacids can make it tougher for Diclofenac Sodium – Misoprostol to absorb in your body. Do not take any antacids without your doctor’s advice. Many medications contain NSAIDs like aspirin, ibuprofen, ketoprofen, or naproxen. Read the medicine labels carefully and avoid NSAIDs while taking this medication. Alcohol consumption is also not recommended while taking Diclofenac Sodium – Misoprostol.
Side Effects due to Diclofenac Sodium – Misoprostol
Diclofenac Sodium – Misoprostol gastro medication (Arthrotec) like all medications has the potential of causing side effects. Some of the common side effects due to this medication are black, bloody or tarry stools; bloody cough or vomit that looks like coffee grounds; increased blood pressure; diarrhea; upset stomach; nausea; heartburn; stomach pain; constipation; or drowsiness.
The side effects mentioned above are the not the only ones and there may be other side effects which may be rare and serious. Seek medical attention immediately if you get serious side effects while taking Diclofenac Sodium – Misoprostol medication. You may also report your side effects to FDA by calling in at 1-800-FDA-1088.
Diclofenac Sodium – Misoprostol Dosing Information
Diclofenac Sodium-Misoprostol dosage will be fixed by your doctor after examining you properly. Dosage may depend on a range of factors like age, sex, drug allergies, or seriousness of the condition among several other factors. Stick to your doctor’s prescription strictly.
Interaction with other drugs
Some drugs can interact with Diclofenac Sodium – Misoprostol. Let your doctor know in advance if you are using any of these interacting drugs presently: blood thinner like warfarin, cyclosporine, digoxin, diuretic, insulin or oral diabetes medications, lithium, methotrexate, steroids, voriconazole, aspirin or other NSAIDs, or an ACE inhibitor like benazepril, enalapril, or others.
The drugs mentioned here are not the only ones that can interact with Diclofenac Sodium-Misoprostol. There may be others as well. Share the list of all types of medications and related products which you are using with your doctor and never start a new medication without his or her advice.
What is Arthrotec 75mg/200mcg used for?
Arthrotec 75mg/200mcg is a combination tablet of diclofenac Sodiumium 75mg and misoprostol 200mcg. It is prescribed for patients with osteoarthritis or rheumatoid arthritis who need NSAID therapy but face a high risk of NSAID-induced gastrointestinal ulceration. The higher diclofenac dose (75mg versus 50mg) provides stronger anti-inflammatory effect, while misoprostol provides integrated gastroprotection by replacing the prostaglandins that diclofenac depletes. Arthrotec 75mg is typically dosed twice daily, delivering 150mg of diclofenac per day — the maximum standard daily dose — and is used across the USA, UK, and Australia.
What is the difference between Arthrotec 50mg/200mcg and Arthrotec 75mg/200mcg?
The key difference between Arthrotec 50mg/200mcg and Arthrotec 75mg/200mcg is the diclofenac dose — 50mg versus 75mg per tablet. The misoprostol dose (200mcg) is the same in both. Arthrotec 50mg is typically taken three times daily, delivering 150mg diclofenac/day and 600mcg misoprostol/day. Arthrotec 75mg is taken twice daily, delivering the same 150mg diclofenac/day but only 400mcg misoprostol/day. The twice-daily dosing of Arthrotec 75mg often improves compliance. Arthrotec 75mg is commonly preferred in rheumatoid arthritis patients where twice-daily convenience matters, while 50mg three times daily is used where lower per-dose NSAID exposure is preferable.
How should Arthrotec 75mg/200mcg be taken?
Arthrotec 75mg/200mcg is taken twice daily — one tablet in the morning and one in the evening, both with food. Taking with meals is important to reduce misoprostol-related gastrointestinal side effects including diarrhoea and abdominal cramping. Swallow the tablet whole — do not split, crush, or chew. Avoid magnesium-containing antacids concurrently as they can worsen misoprostol-related diarrhoea. The full anti-inflammatory effect of diclofenac typically becomes noticeable within 1–2 weeks of regular dosing. Do not exceed the prescribed twice-daily dosing regimen, as higher doses significantly increase the risk of cardiovascular and gastrointestinal adverse events.
How long can I safely take Arthrotec 75mg/200mcg?
Arthrotec 75mg/200mcg should be used for the shortest duration compatible with adequate arthritis management. For osteoarthritis, intermittent courses tied to flare periods may be appropriate. For rheumatoid arthritis, long-term use under specialist supervision is common but requires regular monitoring of renal function, blood pressure, liver enzymes, and cardiovascular status. NSAID guidelines recommend reviewing the ongoing need for Arthrotec at each clinical visit and stepping down to lower doses or switching to non-NSAID analgesia when disease activity allows. Proton pump inhibitor co-prescribing is sometimes added for patients on long-term Arthrotec who develop gastrointestinal symptoms despite misoprostol.
Is Arthrotec 75mg/200mcg safe for patients with hypertension?
Arthrotec 75mg/200mcg should be used with caution in patients with hypertension. Diclofenac, like all NSAIDs, causes Sodiumium and water retention, raising blood pressure and potentially reducing the efficacy of antihypertensive medications including ACE inhibitors, angiotensin receptor blockers, and diuretics. Blood pressure should be monitored closely when starting Arthrotec in hypertensive patients. The cardiovascular risk of diclofenac is higher than some other NSAIDs — it is associated with greater thrombotic event risk than naproxen. For patients with significant cardiovascular disease, the risks and benefits of Arthrotec must be carefully weighed by the prescribing physician.
Can Arthrotec 75mg/200mcg be taken with blood pressure medications?
Arthrotec 75mg/200mcg (diclofenac) can interact with antihypertensive medications. NSAIDs reduce the effectiveness of ACE inhibitors and angiotensin receptor blockers and can cause acute kidney injury when combined with these agents — the 'triple whammy' effect when a diuretic is also present. Diclofenac attenuates the antihypertensive effect of beta-blockers and calcium channel blockers. Blood pressure should be monitored after initiating Arthrotec in patients on antihypertensives, with medication adjustment as needed. If blood pressure becomes uncontrolled or renal function deteriorates, Arthrotec should be stopped and alternative pain management considered with the prescribing physician.
How does Arthrotec 75mg/200mcg compare to celecoxib for arthritis?
Arthrotec 75mg/200mcg (diclofenac + misoprostol) and celecoxib are both prescribed for arthritis patients at gastrointestinal risk, but through different mechanisms. Celecoxib is a selective COX-2 inhibitor that preserves COX-1-mediated gastric prostaglandins, reducing ulcer risk without requiring misoprostol. Studies show celecoxib has a better upper GI safety profile than diclofenac alone but similar rates to Arthrotec with misoprostol. Cardiovascular risk is similar between diclofenac and celecoxib. Celecoxib has a simpler dosing regimen (no GI side effects from misoprostol), while Arthrotec offers a lower cost in some markets. Physician and patient factors guide the choice.
Is Arthrotec 75mg/200mcg better than Voveran (diclofenac) alone?
For patients at gastrointestinal risk — older age, prior ulcer history, corticosteroid or anticoagulant use — Arthrotec 75mg/200mcg is significantly safer than diclofenac (Voveran) alone. Clinical studies show misoprostol in Arthrotec reduces the incidence of endoscopically confirmed ulcers by up to 80% compared to diclofenac monotherapy. For patients with no gastrointestinal risk factors, adding misoprostol may be unnecessary and its GI side effects (diarrhoea, cramping) reduce tolerability. Your gastroenterologist or rheumatologist will advise whether the protection of Arthrotec 75mg outweighs the additional side effects compared to prescribing diclofenac with a PPI.
Where can I buy Arthrotec 75mg/200mcg affordably?
Arthrotec 75mg/200mcg is available at AllDayChemist, a licensed pharmacy serving patients in the USA, UK, Australia, and most of the countries since 2002. AllDayChemist supplies authentic diclofenac/misoprostol combination tablets from licensed manufacturers at competitive prices compared to branded Arthrotec at retail pharmacies. Worldwide tracked delivery and discreet packaging are standard. Arthrotec is a prescription-only medicine — confirm suitability with your rheumatologist or GP before ordering. Women of childbearing age must not take Arthrotec without contraceptive coverage, as misoprostol carries serious pregnancy-related risks.
Does AllDayChemist ship Arthrotec 75mg/200mcg to the USA and UK?
Yes, AllDayChemist ships Arthrotec 75mg/200mcg to the USA, UK, Australia, and most of the countries. Since 2002, AllDayChemist has provided reliable international pharmaceutical supply with discreet packaging and worldwide tracked shipping. For US customers, Arthrotec requires a prescription and is subject to FDA import guidelines for personal-use quantities. UK customers should check MHRA guidance on importing prescription NSAIDs. AllDayChemist's competitive pricing on diclofenac/misoprostol combination products makes it a practical choice for arthritis patients managing long-term medication costs in countries where branded Arthrotec is expensive.
What are the most common side effects of Arthrotec 75mg/200mcg?
The most frequently reported side effects of Arthrotec 75mg/200mcg are gastrointestinal, predominantly from misoprostol: diarrhoea, abdominal pain, nausea, and flatulence. These typically occur early in treatment and can be reduced by taking the tablet with food. Diclofenac-related effects include dyspepsia, headache, dizziness, oedema, and elevated blood pressure. More serious risks include cardiovascular events (MI, stroke), hepatotoxicity, renal impairment, and severe cutaneous reactions (Stevens-Johnson syndrome). The combination does not eliminate ulcer risk entirely — patients developing new GI symptoms during therapy should be assessed promptly. Diarrhoea from misoprostol usually diminishes after the first 2–4 weeks.
Can Arthrotec 75mg/200mcg harm an unborn baby?
Yes. Misoprostol in Arthrotec 75mg/200mcg is a potent uterotonic agent that can cause uterine contractions, miscarriage, premature birth, and serious birth defects including Möbius sequence (cranial nerve palsy and limb defects) in fetuses exposed in utero. Diclofenac also causes fetal harm — NSAIDs cause premature closure of the ductus arteriosus and oligohydramnios when used in the third trimester. Arthrotec 75mg/200mcg carries a black box warning in the USA and is strictly contraindicated in pregnancy. Women of childbearing potential must use effective contraception throughout therapy. A pregnancy test before initiation is strongly recommended.
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