Syncapone (37.5+200+150)mg

Do not take Syncapone on Levodopa, carbidopa, Entacapone, or any inactive medicine ingredients. This triple combination drug should be avoided if you have narrow-angle glaucoma, liver disease, or an adrenal gland tumour. Certain medicines for treating depression (combinations of selective MAO-A and MAO-B inhibitors) can interact with Levodopa/carbidopa/entacapone, therefore, should be avoided. Syncapone may increase the effects of certain other medicines. These include medicines to treat respiratory diseases, severe allergic reactions, heart diseases, low blood pressure, and Parkinson’s disease. Consult your doctor if, during the treatment with Syncapone (37.5+200+150), you notice symptoms that your muscles get very rigid or if you get tremors, confusion, agitation, rapid muscle, fever, rapid impulse, or fluctuations in your blood pressure.

Inform your health care specialist notices you are developing urges or cravings to behave unusually or you can’t resist the impulse, drive, or temptation to carry out certain activities that could harm yourself or your loved ones. Such behaviour comes under impulse control disorders, including excessive eating, addictive gambling, an abnormally high sex drive or a preoccupation with increased sexual thoughts.

Experience with Syncapone in patients under 18 years is limited. Therefore, this combination of medicine in children or adolescents is not recommended. The triple combination drug lower blood pressure, which may make you feel light-headed or dizzy. Therefore, be careful while driving or using any tools and medicines.   

Common side effects reported with Syncapone include dyskinesias and other involuntary movements, nausea, diarrhoea, muscle pain, and harmless reddish-brown urine discolouration. Other side effects have been reported with carbidopa/levodopa/entacapone include asthenia, chest pain, cardiac irregularities, inability to sleep, hallucinations, blurred vision, muscle cramps, headache, joint pain, decreased weight, increased sweating,  swelling of legs, shortness of breath, mental changes, and urinary tract infections.

If you get any side effects, speak to your doctor. This includes any possible side effects not listed in the information guide.  

Treatment should be individualized and adjusted for each patient as per the desired therapeutic response. The tablet should not be fractioned; only one pill is taken at each dosing interval. Syncapone should be used as a substitute for patients already stabilized on equivalent doses of carbidopa-levodopa and Entacapone. However, some patients who have been stabilized on a given dose of carbidopa-levodopa may be treated with Syncapone if a decision has been made to include Entacapone. The optimal damage daily dosage of this triple combination medicine must be evaluated by careful titration in each patient. If you have any further questions related to medical use, please ask your doctor.