Available Dosages
| SKU: | 871 |
|---|---|
| Generic For: | Zantac |
| Active Ingredient: | Ranitidine |
| Manufacturer: | Cadila, India |
Buy Aciloc 300mg (Ranitidine) Online
Aciloc 300mg is a prescription oral tablet containing Ranitidine Hydrochloride 300mg, a histamine H2-receptor antagonist used for the treatment and prevention of acid-related gastrointestinal disorders, including peptic ulcer disease, gastro-oesophageal reflux disease (GERD), and pathological hypersecretory conditions. Aciloc 300mg provides the standard twice-daily or once-daily therapeutic dose of Ranitidine — the H2-blocker with the most extensive clinical evidence base among the agents in its class — for conditions where suppression of gastric acid secretion is the primary therapeutic objective. The 20-tablet pack accommodates the full acute treatment course for peptic ulcer disease (typically 4 to 8 weeks) or provides a month’s supply for twice-daily dosing in chronic GERD management, offering a practical and economical packaging unit for both acute and maintenance indications.
What is Aciloc 300mg?
Aciloc 300mg is an oral tablet formulation of Ranitidine 300mg, used at this dose as a once-daily or twice-daily agent depending on the clinical indication. For duodenal ulcer treatment, 300mg at bedtime as a single nocturnal dose has been shown in clinical trials to achieve ulcer-healing rates equivalent to the 150mg twice-daily regimen — providing the practical advantage of a single bedtime tablet for the majority of patients. For maintenance prevention of duodenal ulcer recurrence, 150mg at night is the standard dose, while 300mg nightly may be used in patients with more frequent recurrence or high acid output. For GERD and oesophagitis, 150mg twice daily or 300mg twice daily are used, depending on severity, with the higher dose reserved for patients with confirmed oesophagitis or partial response to lower doses.
Manufacturer: Aciloc 300mg is manufactured by Zydus Cadila. The Aciloc brand is among the most widely dispensed H2-blocker products in India, reflecting the company’s consistent manufacturing quality and the broad clinical utility of Ranitidine in gastroenterology practice.
Active Component of Aciloc 300mg
Ranitidine, the active ingredient in Aciloc 300mg, is a selective, competitive antagonist of histamine at the H2 receptors located on the basolateral membrane of gastric parietal cells. Gastric acid secretion is stimulated by three primary pathways: histamine (released from enterochromaffin-like cells in the gastric mucosa), gastrin (released from G-cells in response to food), and acetylcholine (from the vagus nerve). Histamine acts as the final common amplifier of acid secretion by potentiating the effects of both gastrin and acetylcholine, as well as by directly stimulating parietal cell H2 receptors to activate the proton pump (H+/K+ ATPase). By competitively blocking H2 receptors, Ranitidine interrupts the histamine-driven amplification of acid secretion, reducing basal and stimulated acid output by 70 to 80% at the 150mg dose, with the 300mg dose providing more sustained acid suppression, particularly during the nocturnal period when basal acid secretion is highest.
The nocturnal acid suppression effect of Ranitidine is particularly relevant to peptic ulcer healing: duodenal ulcers are driven by nocturnal acid exposure (when the buffering effect of food is absent), and achieving sustained overnight acid suppression is the key pharmacological objective for ulcer healing. Ranitidine 300mg administered at bedtime maintains intragastric pH above 3 for a prolonged nocturnal period, dramatically reducing the acid exposure responsible for ulcer perpetuation. This pharmacodynamic profile — strong nocturnal acid suppression from a single bedtime dose — is the rationale for once-nightly 300mg dosing in duodenal ulcer disease.
Clinical Uses of Ranitidine 300mg
Aciloc 300mg is used for the treatment of active duodenal ulcer (4 to 8 weeks), gastric ulcer (8 weeks), prevention of NSAID-induced gastroduodenal ulcers in high-risk patients, treatment and management of symptomatic GERD and reflux oesophagitis, and pathological hypersecretory conditions including Zollinger-Ellison syndrome. For duodenal ulcer treatment, the bedtime 300mg dose achieves healing rates of 80 to 90% at 4 weeks, a response rate comparable to proton pump inhibitors for uncomplicated ulcers. However, PPIs are now preferred for H. pylori eradication-based regimens. In NSAID gastropathy prevention, H2-blockers are used in patients with a history of peptic ulcer disease who require ongoing NSAID therapy for musculoskeletal conditions, providing a protective layer of acid suppression that reduces the risk of ulcer recurrence. For maintenance therapy, lower doses are typically used; 300mg nightly maintenance is reserved for patients with high recurrence risk.
Comparing Aciloc 300mg and Zantac 300mg: Brand vs Generic Differences
Zantac 300mg (GSK/Sanofi) was the originator-branded Ranitidine product. The reference formulation in pivotal clinical trials established Ranitidine as the world’s first blockbuster H2-blocker and demonstrated its efficacy in peptic ulcer disease and GERD. Aciloc 300mg contains Ranitidine Hydrochloride 300mg, formulated to deliver bioequivalent plasma Ranitidine exposure to the reference product, confirming equivalent H2 receptor blockade, equivalent acid suppression, and equivalent clinical ulcer healing efficacy. The extensive clinical database accumulated with branded Zantac — ulcer-healing rates, GERD symptom relief, and safety and tolerability over decades of use — is fully applicable to Aciloc as a bioequivalent generic formulation.
Related strengths and products: Patients requiring a lower dose of Ranitidine for mild GERD or maintenance therapy may be prescribed Aciloc 150mg, the standard twice-daily dose for GERD. For conditions requiring the most potent acid suppression available — including severe erosive oesophagitis or Helicobacter pylori eradication regimens — proton pump inhibitors such as omeprazole or pantoprazole may be appropriate; a gastroenterologist or physician will guide this choice.
Key Benefits of Aciloc 300mg
Aciloc 300mg delivers therapeutic Ranitidine at the dose proven to achieve the fastest and most complete healing of duodenal and gastric ulcers, with the convenience of a once-daily bedtime regimen that maximises the nocturnal acid suppression most relevant to ulcer healing. The established 40-year clinical track record of Ranitidine provides a very well-characterised efficacy and safety profile that prescribers and patients can rely on with confidence.
Usage warnings and precautionary advice for using Ranitidine 300mg
Ranitidine requires dose reduction in patients with significant renal impairment, as it is partially renally excreted; reduced dosing intervals are typically recommended when creatinine clearance falls below 50 ml/min. Ranitidine may mask symptoms of gastric cancer; patients with warning signs — unexplained weight loss, dysphagia, haematemesis, iron-deficiency anaemia — should undergo endoscopic investigation before initiating H2-blocker therapy. Ranitidine inhibits gastric acid secretion, which can reduce the absorption of pH-dependent medications (e.g., ketoconazole, itraconazole, atazanavir); dose timing adjustments may be needed. In patients with porphyria, Ranitidine has been associated with rare acute attacks. Elderly patients may experience more pronounced CNS effects at higher doses.
Side effects of Ranitidine 300mg
Aciloc 300mg is well tolerated in the majority of patients. Headache is the most commonly reported adverse effect, occurring in 3-6% of patients. Gastrointestinal side effects — nausea, constipation, and diarrhoea — occur in a small proportion of users and are typically mild. CNS effects, including dizziness, confusion, and somnolence, have been reported, particularly in elderly patients and in those with renal impairment, where accumulation may occur. Elevated liver enzymes have been reported rarely; jaundice and hepatitis are very uncommon. Reversible thrombocytopenia has occurred rarely. Gynaecomastia and loss of libido have been reported with long-term high-dose use. Hypersensitivity reactions, including rash and, rarely, anaphylaxis, have been observed.
Benefits of Buying Aciloc 300mg Online from AllDayChemist
AllDayChemist offers Aciloc 300mg at competitive prices, with reliable international home delivery, making this widely used acid-control medication accessible to patients who require a full treatment course for peptic ulcer disease or ongoing management of GERD. AllDayChemist’s convenient online ordering, prescription upload facility, and dependable worldwide shipping ensure that patients can maintain their prescribed treatment without the inconvenience of repeated visits to a local pharmacy.
Proper dosage and usage guide of Ranitidine 300mg
For duodenal ulcer treatment, take one Aciloc 300mg tablet at bedtime, or as directed by your physician. For gastric ulcers or GERD medicine, the prescriber will specify the dose and frequency based on severity. Tablets should be swallowed whole with water, with or without food. For NSAID gastropathy prevention, take as directed alongside the NSAID medication. Complete the full prescribed course, even if symptoms improve before completion; premature discontinuation increases the risk of recurrence. If a bedtime dose is missed, take it when you remember, unless it is already close to morning. Do not exceed the prescribed dose. Antacids can be taken concurrently if needed for immediate symptom relief. Store below 30°C in a dry, light-free place.
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