| SKU: | 341 |
|---|---|
| Generic For: | Motilium |
| Active Ingredient: | Domperidone |
| Manufacturer: | Cipla, India |
Buy Vomistop 10mg (Domperidone) Online
Vomistop 10mg is an oral gastrointestinal motility regulator containing 10mg of Domperidone, used for the relief of nausea, vomiting, and symptoms of delayed gastric emptying. Manufactured by Dr. Reddy’s Laboratories, Vomistop is a widely prescribed antiemetic and prokinetic agent that works primarily at the periphery — in the gastrointestinal tract and at the chemoreceptor trigger zone — without crossing the blood-brain barrier to any significant extent, which limits central nervous system side effects. It is used across a range of clinical scenarios, including nausea from gastrointestinal conditions, functional dyspepsia, and post-chemotherapy or post-operative nausea.
What is Vomistop 10mg?
Vomistop 10mg is an oral tablet containing Domperidone 10mg, a dopamine D2 and D3 receptor antagonist with prokinetic and antiemetic properties. It is indicated for the relief of nausea and vomiting of various causes, bloating and postprandial fullness in functional dyspepsia, and gastroparesis (delayed gastric emptying). Unlike metoclopramide — a related prokinetic — Domperidone has limited penetration through the blood-brain barrier, significantly reducing its risk of central dopamine antagonism and associated extrapyramidal side effects (tardive dyskinesia, dystonia). It acts primarily on peripheral dopamine receptors in the gastrointestinal wall and at the area postrema (chemoreceptor trigger zone), which lies outside the blood-brain barrier. The 10mg dose is the standard adult dose taken before meals.
Manufacturer: Vomistop 10mg is manufactured by Dr. Reddy’s Laboratories, a leading multinational Indian pharmaceutical company with a global presence and a respected portfolio of gastrointestinal and speciality medicines.
Key Ingredients of Vomistop 10mg and Their Working Process
Domperidone is a selective peripheral dopamine D2/D3 receptor antagonist. In the gastrointestinal tract, dopamine inhibits motility — it reduces lower oesophageal sphincter tone, slows gastric emptying, and reduces peristalsis. By blocking these inhibitory dopamine receptors, Domperidone increases lower oesophageal sphincter pressure (reducing reflux), accelerates gastric emptying, and coordinates antroduodenal peristalsis — promoting the orderly movement of stomach contents into the small intestine. This prokinetic effect relieves bloating, postprandial fullness, nausea, and vomiting associated with gastroparesis and functional dyspepsia. At the chemoreceptor trigger zone (CTZ), which lies outside the blood-brain barrier, Domperidone blocks dopamine receptor-mediated emetic signals, reducing the frequency and severity of nausea and vomiting from metabolic, drug-induced, and gastrointestinal causes.
Clinical Uses of Domperidone
Domperidone 10mg is clinically indicated for nausea and vomiting in adults regardless of cause — including gastrointestinal illness, medication-induced nausea (particularly dopaminergic drugs used in Parkinson’s disease), post-operative nausea, and functional dyspepsia. It is used in gastroparesis to improve gastric emptying. It is also used in breastfeeding women as a galactagogue (off-label, to increase breast milk production) due to its prolactin-elevating effect via pituitary dopamine receptor blockade. Domperidone is generally considered preferable to metoclopramide for prolonged use due to its lower central side effect risk. Its use is limited to the lowest effective dose for the shortest necessary duration due to cardiac safety considerations at higher doses.
Comparing Vomistop and Motilium: Brand vs Generic Differences
Vomistop 10mg is the generic equivalent of Motilium 10mg (Janssen Pharmaceutica), the original branded Domperidone product. Both contain Domperidone 10mg, are bioequivalent, and produce identical gastrointestinal and antiemetic effects. Motilium commands a premium price, while Vomistop from Dr. Reddy’s delivers the same clinical benefit at a lower cost. Dr Reddy’s is a globally respected pharmaceutical manufacturer, ensuring the same quality and pharmaceutical standards as its branded products.
Related strengths and products: Vomistop is also available in suspension and drop formulations for paediatric use and patients who cannot swallow tablets. Domperidone 30mg slow-release capsules are available for patients requiring sustained-release therapy. For nausea associated with chemotherapy or post-operative states, 5-HT3 antagonists such as Ondansetron may be preferable and are available separately.
Key Benefits of Vomistop 10mg
Vomistop 10mg provides effective relief from nausea, vomiting, and dyspeptic symptoms with a significantly lower risk of central nervous system side effects compared to metoclopramide. Its prokinetic action addresses the underlying cause of symptoms in gastroparesis and functional dyspepsia rather than simply masking nausea. As a Dr Reddy’s product, it offers pharmaceutical-grade quality at a cost accessible for short-term, intermittent therapeutic use.
Usage warnings and precautionary advice for using Domperidone
Vomistop 10mg should be used with caution due to its association with QT prolongation and increased risk of serious ventricular arrhythmias at doses exceeding 30mg/day, in elderly patients, and in those with underlying cardiac conduction abnormalities. It is contraindicated in patients with significant hepatic impairment (as Domperidone is extensively hepatically metabolised), known prolonged QT interval, or a history of cardiac arrhythmias. It must not be used concurrently with QT-prolonging medications — including azithromycin, clarithromycin, haloperidol, amiodarone, and several antifungal agents. CYP3A4 inhibitors significantly increase Domperidone plasma levels. It is not recommended in patients with prolactinoma or other prolactin-dependent tumours due to its prolactin-elevating effect. Renal function may require dose reduction in severe impairment. Not recommended in children under 12 years of age or weighing less than 35kg.
Side effects of Domperidone
Dry mouth and drowsiness are the most commonly reported mild side effects. Headache, diarrhoea, and abdominal cramping occur occasionally. Breast tenderness, galactorrhea, and menstrual irregularities may occur with prolonged use due to elevated prolactin levels. Extrapyramidal side effects — including dystonia, tardive dyskinesia — are significantly less common than with metoclopramide but are not impossible, particularly in children and with prolonged use. The most clinically serious concern is QT prolongation and the risk of ventricular arrhythmias — cardiac monitoring is recommended for patients requiring long-term treatment. Any palpitations, dizziness, or fainting should be reported immediately.
Benefits of Buying Vomistop 10mg Online
AllDayChemist provides patients with affordable, convenient access to authentic Vomistop 10 mg at prices well below branded Motilium alternatives. For patients managing recurrent gastrointestinal conditions or requiring a reliable supply of antiemetics, AllDayChemist offers worldwide shipping, discreet delivery, and a simple ordering process. Competitive pricing makes maintaining access to quality gastrointestinal therapy cost-effective for ongoing use.
Proper dosage and usage guide of Domperidone
Take one Vomistop 10mg tablet orally three times daily, 15 to 30 minutes before meals. Swallow with water. For best results in dyspepsia and gastroparesis, take before meals to maximise the prokinetic effect on gastric emptying. For nausea and vomiting, doses may be taken as needed up to 3 times daily. The maximum daily dose is 30mg (three 10mg tablets per day) in adults. Do not exceed the recommended dose. Use the lowest effective dose for the shortest duration necessary — generally no longer than one week for acute nausea. For ongoing conditions such as gastroparesis or Parkinson ’s-related nausea, long-term use should be supervised by a physician with ECG monitoring due to cardiac safety concerns. Store at room temperature (15–30°C) in a dry, light-protected location.
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