Available Dosages
| SKU: | 129 |
|---|---|
| Generic For: | Zebeta |
| Active Ingredient: | Bisoprolol |
| Manufacturer: | Unichem, India |
About the drug:
Bisoprolol is a beta adrenergic receptor blocker widely used as an antihypertensive medicine. Beta blockers are the drugs that targets beta receptors present mainly in heart, airways, arteries, smooth muscles and kidneys. They decrease the work load of the heart and helps to beat more regularly and controls mild to moderate high blood pressure.
Uses of the drug:
Bisoprolol is used in the treatment of hypertension, chest pain and heart attack. It is often recommended as a secondary prevention of heart attack. It prevents chest pain and improves survival of a heart attack. It relaxes the blood vessels and reduces the blood pressure & heart rate.
Working of the drug:
Bisoprolol is a beta blocker and is one of the most recommended drugs given in the hypertension. Bisoprolol is a cardio selective beta 1 adrenergic receptor blocker and it gets bind with beta receptors in the heart and vascular smooth muscles and inhibits their action. This all results in following effects:
• Relaxes the blood vessels and aids smooth arterial blood flow
• Provides oxygen by decreasing energy used by the heart to pump blood around the body
• Reduces workload of the heart and amount of oxygen needed to pump the blood around the body
• Improves survival and prevents future heart attack by correcting improper electrical activity of heart blood vessels resulting in fast or slow heartbeat
Manufacturer:
Corbis is manufactured by Unichem Laboratories, a pharmaceutical giant. It is available on our websites and you can easily buy Corbis 2.5 mg online at alldaychemist.com.
Dosage form and strengths:
Bisoprolol tablets are available in the following three strength combinations on our website:
• Corbis 2.5 mg
• Corbis 5 mg
• Corbis 10 mg
You can buy Corbis 2.5 mg online at alldaychemist.com.
Before you take the drug:
• Do not take the drug if you:
Are allergic to Bisoprolol
Are pregnant or planning to become pregnant
Are breastfeeding as the drug may pass into the breastmilk
• Tell your doctor if you:
Have bronchitis
Have hypotension or low blood pressure
Have liver or kidney disease
Having heart problems like sick sinus syndrome, bradycardia and blockage in heart
Are suffering from hypothyroidism and hyperthyroidism
Have congestive heart failure
Have psoriasis
Have pheochromacytoma
Have blood circulation problems like Raynaud’s disease or peripheral vascular disease
Dosage :
How much to take the drug?
Always take the dose as prescribed by the physician. It is very important to consume medicine timely. The general recommended dose is 5 mg for hypertension patients. In case of congestive heart failure, initial dose starts from 1.25 mg. The dose can be increased or decreased depending upon the patient’s condition and demand. With time, dose adjustments are generally done according to the response of the patient. Always take the medicine as prescribed by the doctor.
Corbis is manufactured by Unichem Laboratories, a pharmaceutical giant. It is available on our websites in the pack of 30 tablets.
How to take the drug?
You must swallow the whole tablet with one glass full of water. Do not crush or chew the tablet. Bisoprolol is taken once daily with or without food. It is the best way to take medicine same time daily because it shows best results and helps to remember when to take the drug.
For how long to take it?
It is important to take the drug as instructed by your doctor. Abrupt discontinuation of medicine can cause adverse reactions. So before stopping the drug intake, always consult physician first.
Overdose:
You may need urgent medical attention if you experience below mentioned symptoms:
• Dizziness
• Confusion
• Shakiness
• Unexplained weight gain
• Swelling of hands and feet
• Red skin rash
• Nausea
• Dizziness
• Fatigue
• Sudden hunger
• Blurred vision
• Pale color
• Sweating or confusion
• Vomiting
• Diarrhea
• Rapid heart rate
Miss dose:
Take it as soon as you remember. If it is almost time for your next dose then skip the dose and take your next dose on the correct time. Do not double up the dose to compensate for the missed one.
Side effects of the drug:
All medicines have their side effects, sometimes they are serious but most of the times they are not. Common side effects are mentioned below:
• Impotency
• Anxiety
• Nervousness
• Numbness
• Insomnia
• Weakness and tired feeling
Serious side effects which need medical attention are as follows:
• Lightheadedness
• Fast heartbeat
• Nausea
• Abdominal pain
• Shortness of breath
• Jaundice
• Depression
• Anxiety
• Pain in arms or shoulders
• Cold feeling in hands and feet
• General illness
• Fatigue
Common drug interactions:
Always inform your doctor about the drugs you are taking till date. This way, doctor is able to give you the list of drugs and other things that may interact with Bisoprolol. here are a few drugs contraindicated with Bisprolol:
• Amiodarone
• Ionidine
• Clonidine
• Digoxin
• Rifampin
• Isocarboxazid
• Selegiline
• Sotalol
• Propranolol
• Phenelzine
• Atenolol
• Metoprolol
• Disopyramide
• Nifedipine
• Diabetes medication like Glimipride and Glypride
• Chlorpropamide
• Nadolol
• Albuterol
• Terbutaline
• Reserpine
Warning:
Things to remember:
• Keep the medicine in a close tight container and out of reach of children
• Don’t use the expired medicine
• Keep a complete record of all the medicines you are taking along with this medicine
• Patients having diabetes may not feel a clinical symptom of fast heart beat due to Bisoprolol. Other low blood sugar symptoms like dizziness, sweating remains unaffected with this drug. So it is recommended to check your blood sugar levels on regular basis
What is Corbis 2.5mg used for?
Corbis 2.5mg contains Bisoprolol fumarate 2.5mg, a highly selective beta-1 adrenergic blocker used for hypertension, heart failure with reduced ejection fraction (HFrEF), and angina. Bisoprolol is one of the three beta blockers with proven mortality benefit in heart failure (along with Carvedilol and Metoprolol Succinate). The 2.5mg dose is used for conservative initiation in heart failure or in elderly patients.
How does Bisoprolol in Corbis 2.5mg work?
Bisoprolol is the most cardioselective beta-1 blocker available, with minimal effect on beta-2 receptors in the airways and peripheral vessels at therapeutic doses. It reduces heart rate, cardiac contractility, and renin release — lowering blood pressure, reducing myocardial oxygen demand, and protecting the failing heart from chronic sympathetic overstimulation. Its high selectivity makes it safer than non-selective beta blockers in patients with mild respiratory disease.
What is the starting dose of Corbis 2.5mg for heart failure?
For heart failure with reduced ejection fraction, CIBIS-II trial-based guidelines recommend starting Bisoprolol at 1.25mg once daily (using a 1.25mg tablet or half of 2.5mg if available), titrating to 2.5mg, then 5mg, then 10mg once daily at two-week intervals. Corbis 2.5mg represents the second titration step. For mild hypertension, 2.5mg may be the starting dose directly. The target heart failure dose is 10mg once daily.
How should Corbis 2.5mg be taken?
Corbis 2.5mg is taken once daily in the morning, with or after a meal. The once-daily dosing convenience (compared to twice-daily metoprolol tartrate) is a major practical advantage of Bisoprolol. Take at the same time each day. Do not crush or chew if it is a scored tablet — swallow whole. If a dose is missed, take it as soon as you remember that morning; if it is afternoon, skip and resume the next morning.
Is Corbis 2.5mg safer than Propranolol or Atenolol in patients with mild asthma?
Yes. Bisoprolol is the most cardioselective beta-1 blocker, with significantly less beta-2 receptor blockade than Propranolol (non-selective) or Atenolol (moderately selective). At 2.5mg, bronchospasm risk in patients with mild, stable asthma is low. A Cochrane systematic review found that cardioselective beta blockers can generally be used with appropriate monitoring in patients with mild reversible airway disease. Avoid in severe or unstable asthma regardless of selectivity.
Can Corbis 2.5mg be used in patients with type 2 diabetes?
Yes. Bisoprolol's high beta-1 selectivity means it has less effect on insulin secretion and glucose metabolism than non-selective beta blockers. It can mask tachycardia as a hypoglycaemia warning sign, but this is less pronounced than with Propranolol. For diabetic patients with hypertension or heart failure requiring a beta blocker, Bisoprolol 2.5mg is a suitable choice. More frequent glucose monitoring is advisable when starting therapy.
How does Corbis 2.5mg compare to Zebeta 2.5mg (Bisoprolol brand)?
Corbis 2.5mg and Zebeta 2.5mg both contain Bisoprolol fumarate 2.5mg. Zebeta is the Duramed/Forest branded US product at premium pricing. Corbis from Sun Pharma is the quality-assured generic equivalent at substantially lower cost. Both produce identical heart rate reduction, blood pressure lowering, and heart failure benefit — with the same high cardioselectivity and once-daily dosing convenience.
Is generic Bisoprolol 2.5mg as effective as Zebeta?
Yes. Generic Bisoprolol 2.5mg is bioequivalent to Zebeta and delivers identical pharmacological effects — heart rate and blood pressure reduction with the same high beta-1 selectivity. The CIBIS-II trial evidence for Bisoprolol's heart failure mortality benefit applies to the generic active molecule. AllDayChemist provides Sun Pharma's Corbis 2.5mg with direct manufacturer sourcing.
Where can I buy Corbis 2.5mg online?
Corbis 2.5mg is available at AllDayChemist with worldwide shipping to the USA, UK, Australia, and 200+ countries. AllDayChemist has operated since 2002, sourcing medicines directly from Sun Pharma. Orders ship in discreet, plain packaging with tracking. Free shipping is available on qualifying orders. Visit AllDayChemist.com.
Why is AllDayChemist a preferred pharmacy for Corbis 2.5mg?
AllDayChemist provides Corbis 2.5mg at prices significantly below Zebeta or comparable beta blockers at US retail. Since 2002, AllDayChemist has served 200+ countries with authentic Sun Pharma medications. Free international shipping on qualifying orders, discreet packaging, and reliable customer support make it the ideal source for long-term heart failure and hypertension management with Bisoprolol.
What side effects does Corbis 2.5mg cause?
At 2.5mg, Bisoprolol is very well tolerated. Side effects are typically mild: slight fatigue, mild bradycardia, cold extremities, and occasional dizziness. Due to its high cardioselectivity, bronchospasm and peripheral vasoconstriction are less common than with less selective beta blockers. Vivid dreams or sleep disturbances are uncommon because Bisoprolol is hydrophilic and has poor CNS penetration. Erectile dysfunction can occur at higher doses.
What precautions apply to Corbis 2.5mg?
Never stop abruptly — gradual tapering prevents rebound tachycardia, angina, or hemodynamic destabilisation in heart failure. Avoid in decompensated heart failure, significant AV block, cardiogenic shock, and sick sinus syndrome. Use caution in severe asthma. Monitor resting heart rate periodically. Inform anaesthetists and surgeons about Bisoprolol use. Diabetics should monitor glucose more carefully. Do not combine with Verapamil or Diltiazem without close cardiac monitoring.
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