Cosart H 50/12.50 mg
Upto 28% OFF
$0.30 - $0.42
Available Dosages
| SKU: | 632 |
|---|---|
| Generic For: | Hyzaar |
| Active Ingredient: | Losartan Potassium + Hydrochlorothiazide |
| Manufacturer: | Cipla, India |
Buy Cosart H 50/12.50 mg (Losartan Potassium + Hydrochlorothiazide) Online
Cosart H 50/12.50 mg treats high blood pressure. It is also effective at lowering the risk of strokes in patients with high blood pressure and an enlarged heart. Lowering high blood pressure helps prevent kidney problems, strokes, and heart attacks. This medicine contains active ingredients, namely losartan and hydrochlorothiazide. Losartan is an angiotensin receptor blocker that relaxes blood vessels to allow blood to flow more easily. Hydrochlorothiazide is a diuretic that makes more urine, making the kidneys more water and salt. This also helps to reduce blood pressure.
Do not take Cosart H 50/12.50mg if you have/are:
— Allergic to losartan, hydrochlorothiazide, or any ingredients of the medicine
— Hypersensitive to other sulfonamide-derived substances
— Severely impaired liver function
— Suffering from gout
— Low sodium, low potassium, or high calcium that can’t be corrected by treatment
— Diabetes or kidney impairment and are treated with a blood pressure-lowering medicine containing aliskiren
— More than three months pregnant. It is also better to avoid combination medicine in early pregnancy.
Speak to your doctor before taking Losartan/hydrochlorothiazide if you:
— Have had skin cancer or developed an unexpected skin lesion during the treatment.
— Experience eye pain or a decrease in vision. Long-term hydrochlorothiazide treatment may increase the risk of some types of skin cancer.
— Experienced breathing or lung problems. If you feel breathless after taking the combination medicine, seek immediate medical help.
Cosart H may cause dehydration and electrolyte imbalance. Let your doctor know if you develop signs and symptoms of dehydration and electrolyte imbalance.
Dizziness or light-headedness may occur once your body adjusts to the medicine. If these effects last or get worse, inform your doctor immediately.
Other common side effects of Cosart H are:
— Muscle pain, leg pain, back pain
— Tiredness, weakness, and chest pain
— Increased potassium levels, decreased haemoglobin levels
— Changes in kidney function
— Insomnia, dizziness
— Nausea, diarrhoea, abdominal pain, and indigestion
If you get any side effects, please speak to your doctor. This includes possible side effects not listed in this information guide.
— Cosart H controls hypertension, but it doesn’t cure it. It is important to take the drug as instructed by your doctor. Even if you feel fine, don’t stop taking medicine. Before discontinuing the medication, consult your doctor first.
— For high blood pressure: The recommended dose of Losartan/hydrochlorothiazide for most patients with high blood pressure is one tablet per day to control blood pressure over 24 hours. The dose may be increased to two tablets once daily. The maximum dose is two tablets per day.
— Try to take the dose daily as prescribed. However, do not take an extra dose if you miss a dose. Just continue with the regular dosing schedule. Please speak to your doctor if you have further questions about the medicine used.
— You are not advised to drink alcohol while taking these tablets. Alcohol and Losartan/hydrochlorothiazide may increase each other’s effects.
What is Cosart H 50/12.5mg?
Cosart H 50/12.5mg is a fixed-dose combination tablet containing Losartan potassium 50mg and Hydrochlorothiazide (HCTZ) 12.5mg. It combines an ARB (Losartan) with a thiazide diuretic (HCTZ) to provide dual-mechanism blood pressure control in a single daily tablet. It is used when Losartan alone has not brought blood pressure to target, and the combination offers significantly greater reduction than either agent alone.
How do the two components in Cosart H 50/12.5mg work together?
Losartan blocks angiotensin II receptors, preventing vasoconstriction and Sodiumium retention. Hydrochlorothiazide increases Sodiumium and water excretion through the kidneys, reducing blood volume. These complementary mechanisms act on different pathways, producing additive blood pressure reduction. Additionally, Losartan counteracts the HCTZ-induced activation of the renin-angiotensin system and prevents the hypokalaemia (low potassium) that HCTZ alone can cause.
How should Cosart H 50/12.5mg be taken?
Take one Cosart H tablet once daily, with or without food, at the same time each day. Morning dosing is preferred as the diuretic component (HCTZ) may increase urinary frequency during the first few hours after dosing — taking it in the morning avoids night-time bathroom trips. Swallow whole with a glass of water. Do not stop taking Cosart H abruptly without medical advice.
Can I switch from separate Losartan and HCTZ tablets to Cosart H 50/12.5mg?
Yes. If you are currently taking Losartan 50mg and HCTZ 12.5mg as separate tablets, switching to Cosart H 50/12.5mg simplifies your regimen to one tablet daily with no change in efficacy. The fixed-dose combination improves adherence. Confirm the switch with your doctor, who will verify you are already stable on equivalent doses before prescribing the combination tablet.
Is Cosart H 50/12.5mg safe in patients with gout?
Caution is required. Hydrochlorothiazide can raise serum uric acid levels, potentially precipitating gout attacks in susceptible individuals. Losartan, however, is the only ARB with a demonstrated uricosuric effect — it lowers uric acid levels, partially offsetting the HCTZ effect. For patients with gout and hypertension, Cosart H may be usable but should be discussed with your doctor, who will monitor uric acid levels.
Can Cosart H 50/12.5mg be used during pregnancy?
No. Both Losartan (ARB component) and Hydrochlorothiazide are contraindicated in pregnancy. Losartan is teratogenic in the second and third trimesters. HCTZ can cause neonatal thrombocytopenia and electrolyte imbalances. Women who become pregnant while taking Cosart H must discontinue it immediately and switch to a pregnancy-safe antihypertensive under obstetric guidance.
Is Cosart H 50/12.5mg equivalent to Hyzaar 50/12.5mg?
Yes. Cosart H 50/12.5mg and Hyzaar 50/12.5mg (the Merck originator brand) both contain Losartan 50mg and Hydrochlorothiazide 12.5mg. They are bioequivalent and therapeutically interchangeable. Hyzaar is sold at premium prices in the USA. Cosart H, available at AllDayChemist, provides the same dual antihypertensive benefit at significantly reduced cost.
Why is the Losartan/HCTZ combination more effective than Losartan alone?
The addition of HCTZ to Losartan activates complementary pathways — HCTZ reduces blood volume while Losartan prevents the compensatory RAAS activation that HCTZ alone would trigger. The result is greater and more durable blood pressure reduction than either agent produces alone. Clinical guidelines recommend ARB + diuretic as a preferred two-drug combination for hypertension, particularly in patients of African descent or those with volume-sensitive hypertension.
Can I buy Cosart H 50/12.5mg at AllDayChemist?
Yes. Cosart H 50/12.5mg is available at AllDayChemist with worldwide shipping to the USA, UK, Australia, and 200+ countries. Operating since 2002, AllDayChemist provides authentic, manufacturer-sourced medicines. Orders ship discreetly with tracking. Free shipping is available on qualifying orders. Visit AllDayChemist.com to order your supply.
What is the cost advantage of buying Cosart H at AllDayChemist?
Cosart H 50/12.5mg at AllDayChemist is priced significantly below what US patients pay for Hyzaar or generic Losartan/HCTZ combinations at local retail pharmacies. Furthermore, a fixed-dose combination replaces two separate prescriptions — reducing both pill burden and total medication cost. Free international shipping on qualifying orders further enhances the value.
What side effects are possible with Cosart H 50/12.5mg?
Side effects from the HCTZ component include increased urination, low potassium (hypokalaemia), elevated uric acid, and photosensitivity. Losartan side effects include dizziness and mildly elevated potassium. In the combination, the potassium effects partially cancel — HCTZ lowers and Losartan raises potassium. Net potassium levels should still be monitored. Dehydration risk increases in hot weather or during illness.
What monitoring is needed with Cosart H 50/12.5mg?
Check electrolytes (Sodiumium, potassium) and creatinine at baseline and three to six months after starting Cosart H 50/12.5mg, then annually if stable. Uric acid levels are relevant in patients with gout history. Use sun protection (SPF 30+) due to HCTZ-associated photosensitivity. Report muscle cramps (possible hypokalaemia), excessive thirst or urination, or dizziness to your doctor. Avoid NSAIDs and potassium-depleting supplements without guidance.
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