Available Dosages
| SKU: | 544 |
|---|---|
| Generic For: | Avapro |
| Active Ingredient: | Irbesartan |
| Manufacturer: | Sun Pharma, India |
Buy Irovel 150mg (Irbesartan) Online
Irovel 150 mg is an oral hypertensive agent having the property of a non-peptide Angiotensin II receptor antagonist. This is one of the most trusted drugs used to treat hypertension. This drug is used alone or with other drugs to treat high blood pressure. Irbesartan, the active ingredient of the medicine, also helps to protect the kidneys from the damage caused due to diabetes. High blood pressure is a big threat to the overall health of various body organs. Hypertension may become the main culprit for heart attacks, strokes and kidney problems.
Irbesartan decreases the heart's workload by blocking the action of Angiotensin; Irbesartan also widens the blood vessels, thus reducing blood pressure. High blood pressure also increases the susceptibility to serious cardiovascular diseases like heart failure, heart attack and angina pectoris. Lowering high blood pressure may prevent heart attacks and various kidney problems.
Do not take Irovel 150 mg if you are allergic to Irbesartan or any other ingredients in the formulation. You should not take this oral antihypertensive agent if you are more than three months pregnant, have diabetes, or have impaired kidney function. Speak to your doctor before taking this medicine, and if you have excessive vomiting or diarrhoea, heart problems, kidney disease, low blood sugar, or are going to have surgery. Let your doctor know if you take other medicines to treat high blood pressure. These include lisinopril, ramipril, enalapril, and aliskiren. If you take certain painkillers, called NSAIDs or non-steroidal anti-inflammatory drugs, the effects of Irovel may be reduced.
Common side effects of Irovel 150 mg include dizziness, feeling vomiting, and blood tests may show elevated levels of an enzyme that measures muscle and heart function. In patients suffering from high blood pressure and type 2 diabetes with kidney disease, dizziness when getting up from a lying or sitting position, a significant drop in blood pressure from a lying or sitting position, and pain in muscles or joints.
Irovel 150 mg is for oral use. Swallow the whole tablet with one glass full of water. Do not crush or chew the tablets. This medicine can be taken once a day. It can be taken with or without food. It is best to take it at the same time each day because it shows the best results and will help you remember the time to take the drug. Also, you should continue to take this medicine until your doctor tells you otherwise.
For patients with high blood pressure, the usual dose is 150 mg once a day. Later, the dose may be increased daily depending on blood pressure response. Your doctor may recommend a lower dose, especially when beginning treatment in certain populations, such as those with haemodialysis or those over 75 years. Irovel is not recommended for use in children under 18 years of age
What is Irovel 150mg used for?
Irovel 150mg contains irbesartan 150mg, an angiotensin II receptor blocker (ARB) prescribed for hypertension and diabetic nephropathy in patients with type 2 diabetes. Irbesartan selectively blocks the AT1 angiotensin receptor, preventing angiotensin II-mediated vasoconstriction, aldosterone secretion, and renal and cardiac damage. The IDNT trial demonstrated irbesartan's specific benefit in slowing the progression of diabetic nephropathy beyond blood pressure reduction alone. Irovel 150mg is a widely used starting dose, with titration to 300mg for patients requiring stronger blood pressure or kidney protection. It is prescribed in the USA, UK, and Australia as an alternative to ACE inhibitors, especially in patients who develop ACE inhibitor-induced cough.
How does irbesartan in Irovel 150mg lower blood pressure?
Irbesartan in Irovel 150mg blocks the angiotensin II type 1 (AT1) receptor in vascular smooth muscle, adrenal cortex, and kidneys. By preventing angiotensin II from binding to its receptor, irbesartan blocks the vasoconstriction, aldosterone-stimulated Sodiumium retention, and sympathetic activation that elevate blood pressure. Unlike ACE inhibitors, ARBs like irbesartan do not inhibit bradykinin breakdown, so they do not cause dry cough. Irbesartan is a non-competitive AT1 antagonist with high receptor affinity and a long half-life (11–15 hours), supporting once-daily dosing with sustained 24-hour blood pressure control. The antihypertensive effect is maximal at 2–4 weeks of continuous therapy.
What is the standard dosing schedule for Irovel 150mg?
Irovel 150mg is taken once daily, with or without food. For hypertension, 150mg is the usual starting dose, titrated to 300mg if blood pressure remains above target after 2–4 weeks. The maximum recommended dose is 300mg once daily — doses above 300mg do not provide meaningful additional antihypertensive effect. For diabetic nephropathy, the IDNT trial used 300mg as the target dose, so titration from 150mg to 300mg is common in this indication. Take Irovel at the same time each day — morning or evening — consistently. Blood pressure should be measured after 2–4 weeks at each dose to assess response before any upward titration.
Can Irovel 150mg be taken with a diuretic?
Irovel 150mg can be combined with a thiazide diuretic (typically hydrochlorothiazide 12.5–25mg) for enhanced blood pressure control when monotherapy is insufficient. This combination is so common that fixed-dose combinations (irbesartan + hydrochlorothiazide) are commercially available. The diuretic promotes Sodiumium and water excretion, and by activating the renin-angiotensin system, it actually enhances the antihypertensive response to irbesartan. When initiating the combination in volume-depleted patients, monitor for first-dose hypotension. The 'triple whammy' effect (ARB + diuretic + NSAID) increases acute kidney injury risk significantly — avoid NSAIDs in patients on this combination.
Is Irovel 150mg safe for elderly patients with hypertension?
Irovel 150mg is generally well tolerated in elderly patients and is a preferred antihypertensive class in this group due to the absence of ACE inhibitor-induced cough. Elderly patients may be more susceptible to first-dose hypotension — starting at 75mg (half tablet) may be advisable in very elderly or frail patients before increasing to 150mg. Renal function and potassium require monitoring as older adults have reduced renal reserve. ARBs are beneficial in elderly hypertensives with comorbid heart failure, diabetes, or CKD. The absence of reflex tachycardia and the once-daily dosing convenience of Irovel 150mg make it a practical choice for elderly patients managing multiple medications.
Does Irovel 150mg affect potassium levels?
Irovel 150mg can raise serum potassium (hyperkalaemia) by blocking aldosterone-mediated potassium excretion in the kidney — the same mechanism as ACE inhibitors. The risk is modest at 150mg when used as monotherapy in patients with normal renal function. Hyperkalaemia risk increases significantly when Irovel 150mg is combined with potassium-sparing diuretics (spironolactone, amiloride), ACE inhibitors (dual RAS blockade — generally avoided), NSAIDs, or in patients with CKD or diabetes. Serum potassium should be checked at baseline and 1–2 weeks after starting Irovel 150mg, then every 3–6 months during stable therapy. Potassium supplements should not be added without confirming hypokalaemia.
How does Irovel 150mg compare to losartan 50mg for hypertension?
Irovel 150mg (irbesartan) and losartan 50mg are both ARBs with comparable antihypertensive mechanisms. Head-to-head studies show irbesartan 150mg provides superior 24-hour blood pressure reduction compared to losartan 50mg, with a flatter blood pressure curve and better trough-to-peak ratio. Irbesartan has a longer half-life than losartan (11–15 hours vs 2 hours, though losartan's active metabolite extends its duration). Irbesartan is specifically approved for diabetic nephropathy (IDNT trial evidence); losartan has nephroprotection data from the RENAAL trial. Both are well tolerated without ACE inhibitor cough. Cost and local formulary availability commonly guide the choice between the two agents.
Is Irovel 150mg or Irovel 300mg better for diabetic kidney disease?
For diabetic nephropathy, the IDNT trial established irbesartan 300mg as the nephroprotective dose — showing a 33% reduction in doubling of serum creatinine, 23% reduction in end-stage renal disease, and significant reduction in proteinuria versus placebo. Irovel 150mg is the starting dose for most patients, with titration to 300mg being the clinical target for kidney protection. The 150mg dose provides meaningful antihypertensive benefit and partial nephroprotection, but 300mg is the evidence-based target dose for slowing diabetic nephropathy progression. If tolerated (blood pressure not excessively lowered, potassium and creatinine stable), titration to Irovel 300mg is recommended in diabetic nephropathy patients.
Where can I buy Irovel 150mg online?
Irovel 150mg is available at AllDayChemist, a trusted licensed pharmacy operating since 2002 and serving most of the countries including the USA, UK, and Australia. AllDayChemist provides authentic irbesartan sourced from licensed pharmaceutical manufacturers at competitive prices compared to branded Avapro 150mg at retail pharmacies. For patients on long-term irbesartan for hypertension or diabetic nephropathy, AllDayChemist offers affordable medication supply with worldwide tracked delivery and discreet packaging. Irbesartan is a prescription medication in most countries — ensure medical supervision, including regular blood pressure and renal function monitoring, is in place before ordering.
Does AllDayChemist deliver Irovel 150mg to the USA?
Yes, AllDayChemist delivers Irovel 150mg to the USA and most of the countries worldwide. With a 20-year track record since 2002, AllDayChemist supplies authentic irbesartan from verified manufacturers with discreet packaging and worldwide tracked delivery. US patients benefit from significantly lower prices on generic irbesartan versus branded Avapro at US retail pharmacies. FDA guidelines permit importation of personal-use quantities of prescription medications from licensed international pharmacies in certain circumstances — verify current regulations before ordering. AllDayChemist's customer service team can assist US customers with any ordering queries for Irovel 150mg.
What are the side effects of Irovel 150mg?
Irovel 150mg is generally well tolerated. Common side effects include dizziness, headache, fatigue, and upper respiratory tract infections. Unlike ACE inhibitors, irbesartan does not cause dry cough — this is one of the main reasons patients are switched from ACE inhibitors to ARBs like irbesartan. Mild hyperkalaemia may occur, particularly in patients with CKD or on concurrent potassium-sparing diuretics. Hypotension can occur, especially in volume-depleted patients. Rare serious adverse effects include angioedema (less common than with ACE inhibitors), acute kidney injury (in renal artery stenosis), and hepatic injury. Irbesartan is teratogenic — contraindicated throughout pregnancy and in women planning to conceive.
Is Irovel 150mg safe for people with diabetes?
Irovel 150mg (irbesartan) is particularly recommended for patients with type 2 diabetes and hypertension, as it provides both blood pressure reduction and kidney protection beyond its antihypertensive effect. The IDNT trial showed irbesartan 300mg specifically reduced the progression of diabetic nephropathy independent of blood pressure lowering. Unlike some antihypertensives, irbesartan is metabolically neutral — it does not worsen glucose control, lipid profiles, or insulin sensitivity. For diabetic patients who have developed ACE inhibitor cough on ramipril, switching to Irovel 150mg (titrating to 300mg) provides equivalent or superior renal protection. Regular monitoring of eGFR, serum potassium, and urine albumin:creatinine ratio is recommended.
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