Leading Online Pharmacy
100% Genuine Products
  Wide Collection of Prescription
& OTC Products
  We Accept eCheck
Secure and Faster payment gateway

Istavel 50mg

100% of 100

Istavel 50 mg Contains Sitagliptin is a prescription medicine used for the treatment of type 2 Diabetes

US$ 0.45

Use this feature to report any issue on product page

More Information
SKU 1011
Generic For Januvia
Generic Name Sitagliptin
Manufacturer Sun Pharma
Pack Size Qty Price Per Pill or Unit Price Cart
50 Tablet/s US$ 0.50 US$ 25.00
100 Tablet/s US$ 0.45 US$ 45.0010%US$ 50.00
Write Your Own Review

Istavel 50 mg

Sitagliptin is an oral medicine for diabetes. It is marketed as salt of phosphate under various brand names. It is a very effective medicine to control diabetes by controlling the sugar level. It is mostly recommended for type 2 diabetes mellitus alone or in combination with other medicines that cure diabetes. It is not recommended to treat type-1 diabetes. This drug is either sold alone or in combination with metformin or Thiazolidinediones (other anti-hyperglycemic agents).

Understanding the drug

Sitagliptin is an oral anti hyperglycemic or anti-diabetic drug containing DPP-4 inhibitors (dipeptidylpeptidase-4 inhibitors) that lowers the blood sugar level.

How it works?

Sitagliptin works by lowering the high blood glucose (hyperglycemia). These are the drugs that increase the secretion of insulin and suppress the release of glucagon by pancreas. This drives the blood glucose levels to normal levels. As soon as the blood glucose levels become normal, then the increased changes in the insulin and glucagon stops and further prevents the hypoglycemic situation.

When should you avoid it?

You should not take this drug if you:

  • Are allergic to Sitagliptin or any of the other ingredients
  • Are pregnant or planning to do so
  • Are breastfeeding
  • Have type-1 diabetes mellitus
  • Have diabetic ketoacidosis
  • Have serious infections
  • Have severe kidney problem
  • Have pancreatitis

How much to take?

The usual starting dose for adults is one 100 mg once a day and the drug dosage varies from person to person. Ask the doctor for the correct dose. Do not take the drug without your doctor’s prescription.

What are the strengths available?

The drug is available in the varying strength of the active ingredient Sitagliptin on our website:

Istavel 25 mg tablet

Istavel 50 mg tablet

Istavel 100 mg tablet

The combination drug of Sitagliptin and metformin is also available:

Janumet 50+500mg

Janumet 50+1000mg

Who is the manufacturer?

Istavel and Janumet (brand names) drugs are both manufactured by a well known pharmaceutical company, Merck Sharp and is available on our websites in the packs of 28, 56 and 84 tablets.

How to take it?

Swallow the tablet with one glass full of water. The drug should preferably be combined with meals if possible. This drug should be combined with well balanced calorie controlled diet, rich in fruits and vegetables.

When to take?

Take this drug during the same time each day, this will make you sure that you don’t forget to take the medicine at the correct time.

For how long should it be taken?

It is very important to take the drug exactly as prescribed by the doctor. Continue to take the medicine as long as the doctor recommends you that. Take the medicine about the same the time each day so as to remember when to take the drug. This medicine controls diabetes but does not cure it hence it is needed to be take it for a longer period of time. The doctor will suggest you about the duration you have to take the medicine.

What if you take too much (overdose)?

Too much Sitagliptin may cause harmful side-effects on body this may result in hypoglycemia (low blood sugar).You may require urgent medical help in this situation. Call for doctor or any other medical help in case you feel any of the following symptoms:

  • Back, muscle or  joint pain
  • Abdominal pain ( severe or mild)
  • Headache
  • Nausea
  • Osteoarthritis
  • Constipation
  • Diarrhea
  • Dizziness

If you feel any other alarming symptoms other than the above listed then immediately consult the doctor about the continuation of this drug. In case of emergency call your doctor or visit the nearest healthcare center immediately.

What if you miss the dose?

In case you miss to take the dose, skip the dose and take the next dose on the recommended time period if it’s too late but if it’s less than 1 hour of the meal then take it normally as you would. Do not double up the dose to make up for the missed one.

What are the side effects?

Tell your doctor as soon as possible if you notice any of the following:

  • soreness in the back of the nose
  • Unusual tiredness
  • Low blood sugar
  • Headache and drowsiness
  • Fast heart rate
  • Feeling drunk
  • Headache
  • Constipation
  • Diarrhea
  • Dizziness and trouble concentrating
  • Unusual bleeding or bruising

In such cases you must go for immediate medical help. Do not get alarmed by the list. You may /may not experience all of them. Tell your doctor immediately in the above situations.

Are there any possible drug interactions?

As the drug is associated with weight loss, ask your doctor about the intake of the cholesterol and diabetes drugs. Also consult your doctor about the following drugs such as:

  • Ivacaftor
  • Probenecid
  • Non-steroidal anti-inflammatory drugs
  • Aspirin or other salicylates
  • Sulfa drugs
  • Monoamine oxidase inhibitors
  • Beta-blockers

Ask your doctor to get the full list of the drugs needed to be avoided while taking the drug as they may interfere it and may cause adverse effects. Also tell him about the herbal or OTC medicine that you are taking or you have been taking. Never start a new medicine without the information of doctor.

What are the things to be taken care of?

  • Your blood sugar will need to be checked often
  • Do not consume alcohol
  • Try to involve in any kind of exercise and take a proper diet to keep a check on blood sugar level.
  • Keep a check on your body weight
  • Always keep a source of sugar available with you like a fruit or candy or gel.
  • Keep the drug readily available
  • Never change the dose or schedule of the medicine without doctor’s advice
  • Do not skip meals while taking this drug


   — Do not take Istavel 50 mg if you are allergic to Sitagliptin or any of the ingredients of the medicine.

   — Cases of inflammation of the pancreas have been reported in patients receiving Sitagliptin.

   — If you develop blistering of the skin, it may be a sign of bullous pemphigoid.


Inform your doctor if you have or have ever had the following:

   — Diabetic ketoacidosis (a complication of diabetes with high blood sugar, nausea, vomiting, and rapid weight loss).

   — Any past or present kidney problems

   — An allergic to Istavel 50 mg 

   — The medical condition can increase your chance of getting pancreatitis

   — Type 1 diabetes

   — A disease of the pancreas   


Sitagliptin is unlikely to cause low blood sugar because it does not work when your blood glucose is low. However, when the medicine is combined with a sulphonylurea drug or insulin, low blood sugar can occur. To reduce this side effect, your doctor may reduce the dose of your sulphonylurea or insulin medicine.


Istavel is not recommended for children and adolescents below 18 years of age. It is ineffective in children and adolescents between the ages of 10 and 17. It is still unknown whether this antidiabetic agent is safe and effective when used in children younger than ten.


Common side effects of Istavel 50 mg include constipation, flu, swelling of the hands and legs, flatulence, headache, and low blood sugar. If you get any side effects, speak to your doctor. This includes possible side effects not listed in this information guide. 

The dosage of Istavel should be individualized based on the patient's current regimen, effectiveness, and tolerability while not exceeding the recommended dose of 100 mg. Initial combination therapy or maintenance or combination therapy should be individualized. Istavel should generally be taken twice a day with meals. The starting dose should be based on the patient's current condition. Your doctor will recommend the best dose to control your blood sugar.


If you have kidney disorders, your doctor may prescribe lower doses. You can take this medicine before or after consuming food. Your doctor may prescribe this medicine alone or with other medications that help lower blood sugar. Diet and exercise can help your body use its blood glucose better. It is important to stay on the diet and exercise regimen recommended by your doctor while taking Sitagliptin tablets.


Contact your doctor immediately if you take more tablets than the prescribed dosage. Continue to take medicine as long as your doctor prescribes it so you can help manage your sugar level. You should not discontinue the medicine without speaking to your doctor. Ask your doctor if you have further questions about this medicine's use.  


Copyright © 2024 AllDayChemist. All rights reserved.