| SKU | 2621 |
|---|---|
| Generic For | Trexal |
| Active Ingredient | Methotrexate |
| Manufacturer | Sun Pharmaceuticals Ltd, INDIA |
| Pack Size | Qty | Price Per Pill or Unit | Price | Cart | |
|---|---|---|---|---|---|
| 30 Tablet/s | US$ 0.64 | US$ 19.20 | |||
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| 60 Tablet/s | US$ 0.58 | US$ 34.5610%US$ 38.40 | |||
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| 90 Tablet/s | US$ 0.44 | US$ 40.0031%US$ 57.60 | |||
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Oncotrex 7.5 mg is used for the treatment of rheumatoid arthritis because of its high potential and effectiveness; it is also effective in patients with juvenile idiopathic arthritis.
Methotrexate, the active ingredient of the medicine, may also work for patients who have undergone an organ transplant because of its anti-inflammatory and immunomodulatory activity. In addition, Methotrexate can be combined with other medicines, and it effectively treats patients with ulcerative colitis, small-cell carcinoma of the lung, breast cancer, carcinoma of the ovary, and epidermal tumours of the head and neck. Methotrexate is strongly recommended over hydroxychloroquine or sulfasalazine as a disease-modifying antirheumatic agent for patients with moderate to high activity.
Oncotrex may also be used for the treatment of severe psoriasis when a patient fails to respond to other treatments. In psoriasis, skin cells in the body grow quickly. Oncotrex tablets destroy these fast-growing cells. Methotrexate has various modes of action, making it an effective treatment for different conditions. It functions by slowing the growth of abnormal cells and decreasing immune system activity in autoimmune conditions.
Things to take care of while taking the Methotrexate tablet
In case of rheumatoid arthritis or psoriasis, it is contraindicated to use Oncotrex 7.5 mg in patients with chronic liver disease, alcoholic hepatitis, cirrhosis or active alcohol use disorder. Patients should not take Methotrexate with renal dysfunction, blood dyscrasias, HIV/AIDs, or those undergoing radiotherapy. The use of Oncotrex is contraindicated for pregnant women due to the risk of embryo-fetal toxicity, including congenital disabilities, miscarriage and developmental abnormalities. Breastfeeding is generally not recommended during methotrexate treatment due to potential risks to the infant. Mothers are advised to wait for at least a week after receiving a high dose of Methotrexate before breastfeeding.
Medications such as phenytoin, sulfonamides, salicylates, oral anticoagulants, and tetracyclines may interact with Oncotrex 7.5 mg. Drugs such as non-steroidal anti-inflammatory drugs (NSAIDs), penicillin, valproate, warfarin, cyclosporin, proton pump inhibitors, and cisplatin increase the risk of Methotrexate toxicity, whereas neomycin, probenecid and aminoglycosides reduce the absorption of Oncotrex. Concomitant use with certain other medicines can increase the risk of severe adverse effects and reduce the effectiveness of Oncotrex. This includes oral antibiotics, such as penicillin and neomycin, as well as antifolate drugs like NSAIDs, pyrimethamine, and dapsone, and nephrotoxic products.
Caution should be taken when using nitrous oxide in patients receiving Oncotrex 7.5 mg, as it may worsen the effects of Methotrexate, increasing the risk of side effects. In such cases, alternative treatments will be considered. Caution is necessary for using this medication in patients who have pre-existing blood disorders, such as leukopenia, thrombocytopenia, hypoplasia, or significant anaemia.
Side effects of Methotrexate tablet
Even a low dose of Methotrexate is not free from side effects. The most common side effects include nausea, vomiting, loss of appetite, and mucosal ulcers.
The side effects are reported in most patients and are easily managed. The most significant side effects of Methotrexate are hepatotoxicity. These adverse effects are similar to folate deficiency and can be treated by adding folic acid with Oncotrex.
Rarely, side effects such as fibrosis, liver steatosis, and cirrhosis occur when taking a low dose of Methotrexate medicine. Over a long duration, ultrasound and liver biopsy are required to determine the liver damage. If you develop any serious side effects that become troublesome or that persist for a longer duration, seek immediate medical help.
How to take a Methotrexate tablet?
A thorough patient evaluation is required before beginning the medical treatment with Oncotrex. The medication is usually administered weekly as a single dose or divided into doses every eight hours over 24 hours. Folate supplementation should be considered for almost all patients to prevent bone marrow suppression. In adult patients, the oral absorption is dependent upon the dose consumed. Please consult your healthcare professional to know the correct dosage for other conditions. Be sure to follow the instructions provided by your healthcare provider when it comes to taking the medicine.
Rheumatoid arthritis: The usual suggested dose is 7.5 mg once a week, which may further be adjusted to obtain an optimal therapeutic response.
For patients with liver insufficiency: Patients with a liver problem may be at increased risk of developing Methotrexate related side effects. Dose reduction or treatment discontinuation needs to be considered based on the severity of the liver impairment.
For people with renal insufficiency: The dose may be reduced in case of severe conditions. High dose is generally recommended for the treatment of various cancers. While it is typically well tolerated by most patients, it carries a risk of significant toxicity, such as acute kidney injury. Close monitoring and appropriate preventive measures are important to reduce the risk of kidney-related complications in patients receiving high-dose Methotrexate.
The safety and effectiveness of the medication have been established in paediatric patients for juvenile idiopathic arthritis, meningeal leukaemia, lymphoblastic leukaemia, osteosarcoma, and non-Hodgkin lymphoma.
Elderly patients: Adjusting the dose according to kidney function is required to mitigate the risk of toxicity.
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