| SKU: | 938 |
|---|---|
| Generic For: | Can Deprenyl |
| Active Ingredient: | Selegiline Hcl |
| Manufacturer: | Intas Pharmaceuticals, India |
Buy Selgin 5 mg (Selegiline Hcl) Online
Selgin 5mg is a prescription oral tablet containing Selegiline Hydrochloride 5mg, a selective and irreversible monoamine oxidase type B (MAO-B) inhibitor used as an adjunct to Levodopa/Carbidopa therapy in the management of Parkinson’s disease. Selgin 5mg works by inhibiting the enzyme responsible for the breakdown of dopamine in the brain, prolonging the effect of both endogenously produced and Levodopa-derived dopamine in the nigrostriatal pathway. It is used to extend the duration of Levodopa’s effect in patients experiencing motor fluctuations — the “wearing off” phenomenon in which the antiparkinsonian effect of Levodopa fades before the next scheduled dose — and may also have neuroprotective properties that could slow the progression of dopaminergic neuron loss in Parkinson’s disease.
What is Selgin 5mg?
Selgin 5mg is an oral tablet containing Selegiline Hydrochloride 5mg, a selective inhibitor of monoamine oxidase B — the isoform of MAO predominantly responsible for the oxidative metabolism of dopamine in the central nervous system. It is used as an adjunct to Levodopa/Carbidopa (or Levodopa/Benserazide) combination therapy in patients with Parkinson’s disease who are experiencing motor fluctuations despite optimised Levodopa dosing. At 5mg taken twice daily (or 10mg once daily in the morning), Selegiline provides sustained MAO-B inhibition that reduces dopamine catabolism, effectively increasing the amount of dopamine available at striatal synapses for each Levodopa dose. Selgin 5mg may also be used as monotherapy in early Parkinson’s disease in selected patients, where its modest symptomatic effect and potential neuroprotective benefit are considered before introducing Levodopa.
Manufacturer: Selgin 5mg is manufactured by Sun Pharma (Sun Pharmaceutical Industries Ltd.), India’s largest pharmaceutical company and a global leader in CNS and neurological medications, with internationally approved manufacturing facilities and a comprehensive Parkinson’s disease treatment portfolio.
Key Ingredients of Selgin 5mg and Their Working Process
Selegiline Hydrochloride 5mg acts as an irreversible and selective inhibitor of MAO-B at clinically used doses. The monoamine oxidase enzymes exist in two isoforms: MAO-A, which preferentially metabolises serotonin, noradrenaline, and tyramine, and MAO-B, which preferentially metabolises dopamine and phenylethylamine. In the dopaminergic neurons of the substantia nigra and striatum — the brain region where dopaminergic cell loss causes the motor symptoms of Parkinson’s disease — MAO-B is the primary enzyme responsible for dopamine breakdown. By irreversibly inhibiting MAO-B, Selegiline prevents the oxidative deamination of dopamine, prolonging its availability at post-synaptic dopamine receptors in the striatum. This mechanism both extends the duration of each Levodopa-derived dopamine pulse. It reduces fluctuations between “on” periods (adequate motor function) and “off” periods (impaired motor function, freezing, rigidity) that characterise the wearing-off phenomenon.
Selegiline is metabolised in the body to amphetamine and methamphetamine metabolites, which contribute modest dopaminergic and noradrenergic effects — accounting for some of its activating properties. Importantly, at the 5 to 10mg daily dose, Selegiline’s MAO-B selectivity is preserved — it does not inhibit MAO-A, and the tyramine cheese reaction associated with non-selective MAO inhibitors is not seen at standard therapeutic doses. This selectivity is the basis for its safety advantage over older non-selective MAO inhibitors and why it can be combined with Levodopa without the hypertensive crises that would otherwise occur.
Clinical Uses of Selegiline 5mg
Selegiline 5mg is indicated as an adjunct to Levodopa therapy in Parkinson’s disease patients experiencing motor fluctuations, specifically the wearing-off phenomenon — the gradual shortening of Levodopa’s effective duration that occurs as the disease progresses and as Levodopa pharmacokinetics become increasingly unpredictable. By inhibiting MAO-B, Selegiline extends the duration of each Levodopa dose’s effective period, reducing the total number of daily off-period hours and improving motor function consistency. In some patients, adding Selegiline can modestly reduce the total daily Levodopa dose, potentially reducing Levodopa-related side effects, including dyskinesias. Selgin 5mg is also used in early Parkinson’s disease — before Levodopa introduction — both for its mild symptomatic benefit (which delays the need for Levodopa) and for its proposed neuroprotective effects, which have been debated but not definitively established in clinical trials.
Comparing Selgin 5mg and Eldepryl 5mg: Brand vs Generic Differences
Eldepryl 5mg (Orion Pharma, also marketed internationally under various brands) is the original branded Selegiline product. Selgin 5mg from Sun Pharma contains the same active ingredient — Selegiline Hydrochloride 5mg — in a bioequivalent oral tablet formulation that delivers the same plasma Selegiline and metabolite concentrations, the same degree of MAO-B inhibition, and the same clinical outcomes in the management of motor fluctuations. Both products achieve equivalent dopamine-preserving effects in the striatum. Eldepryl commands a price premium in markets where it is available, while Selgin from Sun Pharma provides the same evidence-based Selegiline therapy at a significantly lower price — a meaningful consideration for patients with Parkinson’s disease who require ongoing, long-term daily adjunct therapy alongside their Levodopa regimen.
Related strengths and products: For patients with Alzheimer’s disease or cognitive decline requiring treatment alongside Parkinson’s management, AllDayChemist offers Admenta 10mg (Memantine), a NMDA receptor antagonist used in moderate-to-severe Alzheimer’s disease. For patients whose Parkinson’s therapy requires dopamine agonist support or other neurological co-medications, AllDayChemist’s comprehensive neurological medicine catalogue provides access to a broad range of treatment options in one platform.
Key Benefits of Selgin 5mg
Selgin 5mg provides the clinically validated MAO-B inhibitory effect of Selegiline at the standard therapeutic dose, effectively reducing dopamine catabolism in the striatum and extending the functional duration of each Levodopa dose in patients experiencing motor fluctuations. By reducing the duration and frequency of off-periods, it improves the predictability and consistency of motor function throughout the day, enabling patients to maintain independence in daily activities for longer as Parkinson’s disease progresses. Its MAO-B selectivity at 5mg daily means it can be combined safely with Levodopa without the hypertensive food interactions that non-selective MAO inhibitors require dietary vigilance to prevent. As a Sun Pharma product, Selgin 5mg provides reliable, pharmaceutical-grade Selegiline quality at a price that makes long-term adjunct therapy financially sustainable.
Usage warnings and precautionary advice for using Selegiline 5mg
Selegiline has potentially serious interactions with several medication classes that must be strictly avoided. It must not be combined with pethidine (meperidine) or other opioids — this combination can cause a life-threatening serotonin syndrome characterised by agitation, hyperthermia, hypertension, and altered consciousness. Selegiline should not be used concurrently with tricyclic antidepressants or with SSRIs/SNRIs without specialist oversight, as the serotonergic interaction risk, while lower than with non-selective MAO inhibitors, remains a clinical concern. A washout period of at least 14 days after stopping Selegiline is required before starting most antidepressants. The amphetamine metabolites of Selegiline can exacerbate symptoms in patients with psychosis or severe anxiety — use with caution in these patients. Selegiline may enhance the effect of Levodopa and increase Levodopa-related side effects, including dyskinesias, hallucinations, and orthostatic hypotension — dose adjustment of Levodopa may be required after initiating Selegiline therapy. Not recommended in pregnancy or during breastfeeding.
Side effects of Selegiline 5mg
Selgin 5mg is generally well tolerated at the 5mg twice-daily dose. The most commonly reported side effects include nausea and stomach upset — particularly during the first few weeks — which can be mitigated by taking the tablet with food. Insomnia and vivid dreams are reported by some patients, attributable to Selegiline’s amphetamine metabolites, and are avoided by restricting dosing to morning and midday. Dizziness and orthostatic hypotension may occur, particularly in patients also on Levodopa, and are more pronounced at initiation. Agitation, confusion, and hallucinations are reported in some elderly patients or those with pre-existing cognitive impairment. Dyskinesias — involuntary movement side effects of dopaminergic therapy — may increase after starting Selegiline if the Levodopa dose is not adjusted, as the combined dopaminergic effect is greater. Headache, dry mouth, and palpitations are occasionally noted. At standard doses, the tyramine cheese reaction of non-selective MAO inhibitors is not expected.
Benefits of Buying Selgin 5mg Online
AllDayChemist offers Selgin 5mg at competitive prices, with reliable international home delivery, providing a convenient and affordable access channel for Parkinson’s disease patients and their caregivers who require a consistent daily medication supply. Parkinson’s disease management demands uninterrupted therapy — changes in medication availability can significantly disrupt motor control and quality of life. AllDayChemist’s dependable supply chain and easy repeat-order system make it a trusted platform for long-term management of neurological medications.
Proper dosage and usage guide of Selegiline Hydrochloride 5mg
Selgin 5mg should be taken orally with breakfast and lunch — the standard dose is 5mg twice daily (one tablet with the morning meal and one with the midday meal). An alternative regimen of 10mg once daily with breakfast is sometimes used. Selegiline should not be taken in the afternoon or evening, as its amphetamine metabolites can cause insomnia if taken later in the day — morning and midday dosing avoids this. Tablets should be swallowed with water and may be taken with or without food; taking with meals reduces the incidence of nausea. Selgin 5mg is an adjunct to Levodopa therapy, not a replacement — do not alter Levodopa dosing without physician guidance after starting Selegiline, though the physician may reduce Levodopa dose by 10 to 30% after several weeks if dyskinesias become more prominent. Regular monitoring of blood pressure is advisable, particularly during initiation. Store below 30°C in a dry place away from light.
What is Selegiline Hcl and what is it used for?
Selegiline Hcl is a medicine used to help people with Parkinson's disease manage their symptoms. Parkinson's is a condition where the brain gradually loses cells that produce a chemical called dopamine, which helps control movement. When dopamine levels drop, people experience shaking, stiffness, slow movement, and trouble with balance. Selegiline Hcl, found in Selgin 5 mg tablets, helps slow down the breakdown of dopamine in the brain, keeping more of it available. This can help improve movement and make daily activities easier for people living with Parkinson's disease.
How does Selegiline Hcl actually work in the body?
Selegiline Hcl works by blocking an enzyme in your brain called MAO-B, which normally breaks down dopamine. Think of it like putting a guard at the door to protect dopamine from being destroyed too quickly. By slowing down this breakdown process, Selgin 5 mg helps keep dopamine levels higher for longer periods. This extra dopamine stays active in the brain and helps send better signals between nerve cells that control your movement. The result is improved muscle control, less stiffness, and smoother movements for people with Parkinson's disease.
How long does Selgin 5 mg take to start working?
Selgin 5 mg typically begins working within one to two hours after you take it, but you might not notice the full benefits right away. Most people start seeing meaningful improvements in their Parkinson's symptoms after taking this anti-parkinsonian medicine regularly for two to four weeks. The effects build up gradually as the medication maintains steady dopamine levels in your brain. Some people notice small changes sooner, while others need a bit more time. Everyone responds differently to Selegiline Hcl, so patience is important during the first few weeks of treatment.
When and how should I take Selgin 5 mg?
Take Selgin 5 mg exactly as directed by your doctor, usually once or twice daily with breakfast and lunch. Avoid taking it in the evening or at bedtime because Selegiline Hcl can sometimes make you feel more alert and might interfere with sleep. Swallow the tablet whole with water, and try to take it at the same times each day to maintain steady levels in your body. You can take it with or without food, though taking it with meals may help if you experience stomach upset. Always follow your doctor's specific instructions, as they may adjust your dose based on your individual needs.
What should I do if I forget to take a dose of Selgin 5 mg?
If you miss a dose of Selgin 5 mg, take it as soon as you remember, but only if it's still early in the day. If it's already afternoon or evening, skip the missed dose completely and take your next scheduled dose the following morning. Never double up or take two doses at once to make up for a forgotten tablet, as this could increase your risk of side effects. Taking this Parkinson's medicine late in the day might keep you awake at night. Set a daily alarm on your phone to help you remember your regular dosing times.
Is it safe to take Selgin 5 mg for a long time?
Yes, Selgin 5 mg is designed for long-term use in managing Parkinson's disease, and many people take Selegiline Hcl safely for years. Since Parkinson's is a chronic condition that needs ongoing treatment, this anti-parkinsonian medicine helps maintain steady symptom control over time. Long-term use is generally well-tolerated when taken as prescribed. Your doctor will monitor you regularly through check-ups to ensure the medicine continues working well and to watch for any changes in your health. Keep all scheduled appointments so your treatment can be adjusted if needed as your condition changes over time.
Can I take Selgin 5 mg with other medicines I am already on?
Selegiline Hcl can interact with certain medicines, so it's important to tell your doctor about everything you're taking. It should not be combined with antidepressants like fluoxetine or sertraline, cold medicines containing dextromethorphan, or certain pain medicines like meperidine, as these combinations can cause serious reactions. Some blood pressure medicines and other Parkinson's treatments may also need dose adjustments. Your doctor will review all your current medicines to ensure Selgin 5 mg is safe for you. Always inform your doctor and pharmacist about all prescription medicines, over-the-counter products, and supplements you use.
How is Selgin 5 mg different from similar medicines used for Parkinson's disease?
Selgin 5 mg belongs to a group called MAO-B inhibitors, which work differently from other Parkinson's medicines like levodopa or dopamine agonists. While levodopa directly replaces missing dopamine and dopamine agonists mimic dopamine's effects, Selegiline Hcl protects the dopamine your brain still makes from breaking down too quickly. This makes it particularly useful in early Parkinson's or as an add-on treatment. Some people prefer it because it may have fewer movement-related side effects compared to higher doses of levodopa. Your doctor will recommend the best option based on your specific symptoms and disease stage.
Is the generic version containing Selegiline Hcl just as good as the branded medicine?
Yes, generic medicines containing Selegiline Hcl are just as effective as branded versions. Selgin 5 mg delivers the same active ingredient in the same strength and works identically in your body. Regulatory authorities require generic medicines to meet strict standards proving they perform the same way as the original branded product. The main difference is usually the price, with generics costing significantly less while providing the same therapeutic benefits for treating Parkinson's disease. Many people successfully use generic Selegiline Hcl and experience the same symptom control at a more affordable price point.
What side effects can Selegiline Hcl cause?
Common side effects of Selegiline Hcl include trouble sleeping, dizziness, nausea, headache, and dry mouth. Some people experience upset stomach, confusion, or involuntary movements, especially if they're also taking levodopa. You might also notice mild increases in energy or restlessness. Serious but rare side effects include sudden blood pressure changes when standing up, unusual mood changes, hallucinations, or severe headaches. Most side effects are mild and may decrease as your body adjusts to the medicine. Contact your doctor if side effects become bothersome or if you experience chest pain, rapid heartbeat, or severe mental changes.
Who should NOT take Selegiline Hcl or needs to be extra careful with it?
People taking certain antidepressants, particularly SSRIs or tricyclic antidepressants, should not use Selegiline Hcl due to dangerous interactions. Those with a history of stomach ulcers, severe mental health conditions, or uncontrolled high blood pressure need extra caution. Pregnant or breastfeeding women should discuss risks and benefits carefully with their doctor. People with liver problems may need dose adjustments. If you've had unusual reactions to similar medicines or have upcoming surgery, inform your doctor before starting this anti-parkinsonian treatment. Older adults may be more sensitive to side effects and require closer monitoring during treatment.
Where can I buy Selgin 5 mg online and be sure I am getting a genuine medicine?
You can order Selgin 5 mg directly from us at AllDayChemist.com, where we've been serving patients across the USA, UK, Australia, and many other countries since 2002. We source all our medicines, including this anti-parkinsonian treatment containing Selegiline Hcl, directly from licensed manufacturers to guarantee authenticity. We offer competitive pricing on both branded and generic medicines, with discreet packaging and worldwide shipping options including free shipping. Our licensed pharmacy makes reordering easy, and we help with prescription management. When you order from us, you're getting genuine medication backed by over twenty years of trusted service.
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