Irovel H 150/12.50mg
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| SKU: | 546 |
|---|---|
| Generic For: | Avalide |
| Active Ingredient: | Irbesartan HCTZ |
| Manufacturer: | Sun Pharma, India |
Buy Irovel H 150/12.50mg (Irbesartan HCTZ) Online
About the drug:
Irbesartan and Hydrochlorothiazide is a drug combination used for the treatment of high blood pressure. This drug is an oral hypertensive agent combining a non-peptide Angiotensin II receptor antagonist, Irbesartan and a thiazide diuretic, Hctz.
Uses of the drug:
This is one of the most trusted drugs used in the treatment of hypertension. Both the drugs work efficiently in different ways to treat the high blood pressure and heart problem. Irbesartan and Hctz combination drug is given in hypertension or high blood pressure.
Working of the drug:
Irbesartan is a drug that belongs to the class of Angiotensin-II receptor antagonist. It decreases the work load of the heart by blocking the action of Angiotensin; Irbesartan also widens the blood vessels thus reducing the blood pressure. High blood pressure also increases the susceptibility of serious cardiovascular diseases like heart failure, heart attack and angina pectoris.
Hctz drug belongs to the class of diuretics. Diuretics are known to remove excess of fluid from the body by increasing the diluted urine production. It removes salts, water and decreases the fluid circulation in blood vessels. In this way, pressure in the blood vessel is decreased.
Manufacturer:
Irovel H-150/12.50 mg is manufactured by Sun Pharma, India. It is a leading pharmaceutical company. You can easily buy Irovel H-150/12.50 mg online at alldaychemist.com.
Dosage forms and strengths:
Irbesartan tablets are available in the following strengths on our website:
• Irovel H-150/12.50 mg
• CoAprovel-300/12.50 mg
You can buy Irovel H-150/12.50 mg online from alldaychemist.com at reasonable rates.
Before you take the drug:
• Do not take the drug if you:
- Have an allergy to Irbesartan/HCTZ, or any other ingredient contained in this drug
- Are pregnant or planning to become pregnant
- Are nursing a new born baby
• Tell your doctor if you:
- Have diabetes
- Have asthma
- Have or ever had a kidney problem
- Have systemic lupus Erythromatosus
- Are suffering from heart problems like congenital heart problems
- Have liver problems, gout disease, etc.
Dosage:
• How much to take the drug?
The usual dose is one tablet once a day. Doctor will prescribe the best suitable dose for you. The dose can be increased or decreased according to the need and condition of the patient. Always take the drug as prescribed by the doctor. It is very important to consume medicine at the right time.
• How to take the drug?
Swallow the whole tablet with one glass full of water. Do not crush or chew the tablets. This medicine can be taken once in a day. It can be taken with or without food. It is best to take it at the same time each day because it shows best results and will help you remember the time to take the drug. Always take the medicine as instructed by your doctor.
• For how long to take it?
It is important to take the drug as directed by the doctor. Before stopping the drug intake, always consult a physician first because the sudden discontinuation of the drug may result in severe adverse reactions. You can buy Irovel H-150/12.50 mg online from alldaychemist.com at reasonable rates.
Overdose:
In case of accidental over-dosage it is very necessary to contact the doctor immediately or rush to the nearest health care center.
Miss dose:
Take the dose as soon as you remember. But if it is almost time for your next dose, then skip the dose and take your next dose at the correct time. Do not double up the dose to compensate for the missed one.
Side effects of the drug:
All medicines have their side effects, sometimes they are serious, but most of the times they are not. Side effects vary from people to people. Some common side effects are listed below:
• Headache
• Nausea
• Tiredness or weakness
• Pain in stomach or nausea
• Sexual problems
• Change in heart rhythm
• Fainting
• Muscular pain
• Blurred vision
• Dry cough
Common drug interactions of the drug:
Always inform your doctor about the drugs you are taking till date. This way, the doctor is able to decide and give you the list of drugs other things that may interact with Irbesartan. You may have to stop taking one of the medicines if you are on a dose of Irbesartan:
• NSAIDs
• Aliskiren
• Codeine or morphine
• Amantadine
• Cyclosporin
• Carbamazepine
• Potassium supplements
• Anti-diabetic drugs
• Itraconazole
• Enalapril
• Prazosin
• Diclofenac or Ibuprofen
• Benzodiazepines
• Dopamine or Levodopa
• Nicorandil
• Baclofen
• Cortisone etc.
Warning:
Things to remember:
• The drug may make you dizzy hence, do not drive or use machinery
• Keep a complete record of all the medicines you are taking along with this medicine
• The drug may increase your sensitivity to light so avoid venturing out in the sun, sunbathing by using tanning booths
• Don’t use the expired drugs
• Cut on caffeine consumption
• If you experience any allergic reaction after taking this drug then immediately consult with your doctor
What is Irovel H 150/12.50mg used for?
Irovel H 150/12.50mg is a fixed-dose combination tablet containing irbesartan 150mg and hydrochlorothiazide (HCTZ) 12.5mg. It is prescribed for hypertension when a single antihypertensive agent is insufficient to achieve blood pressure targets. The two components act synergistically: irbesartan blocks the AT1 angiotensin receptor, reducing vasoconstriction and aldosterone secretion; HCTZ, a thiazide diuretic, promotes Sodiumium and water excretion, reducing blood volume. The diuretic-induced renin-angiotensin system activation is counteracted by irbesartan, enhancing the response of both drugs. This combination is used in the USA, UK, and Australia when monotherapy with either agent alone provides inadequate blood pressure control.
How does the irbesartan + hydrochlorothiazide combination in Irovel H work?
rovel H 150/12.50mg combines two medicines that work together to control high blood pressure more effectively. Hydrochlorothiazide helps the body remove extra salt and water through urine, which lowers blood volume and reduces pressure on the heart and blood vessels. Irbesartan relaxes blood vessels by blocking the action of angiotensin II, a substance that causes blood vessels to tighten and the body to retain salt. Together, these medicines provide stronger and more balanced blood pressure control than either medicine used alone.
What is the dose schedule for Irovel H 150/12.5mg?
Irovel H 150/12.50mg is taken once daily, at the same time each day, with or without food. Morning dosing is conventional to align the diuretic effect with daytime hours and minimise nocturnal urination. The tablet should not be split or crushed — swallow whole. If further blood pressure reduction is needed beyond this dose, titration to Irovel H 300/12.5mg or Irovel H 300/25mg (higher irbesartan with increased HCTZ) is the next step. Irovel H should not be the initial antihypertensive choice in de novo treatment — it is indicated when monotherapy with one of its components has been established and proven insufficient. Follow your physician's specific dosing guidance.
Can Irovel H 150/12.5mg be taken during pregnancy?
No. Irovel H 150/12.50mg is strictly contraindicated throughout pregnancy. Both components are harmful to the fetus: irbesartan (ARB) causes fetal renal dysfunction, oligohydramnios, pulmonary hypoplasia, and neonatal death in the second and third trimesters — the same teratogenic profile as all RAS blockers. Hydrochlorothiazide reduces placental blood flow, can cause fetal electrolyte disturbances, neonatal thrombocytopenia, and neonatal jaundice. If a woman taking Irovel H becomes pregnant, she must stop immediately and switch to pregnancy-safe antihypertensives (labetalol, methyldopa, nifedipine) under urgent medical guidance. Women of childbearing potential must use effective contraception throughout therapy.
Are there any kidney concerns with taking Irovel H 150/12.5mg?
Irovel H 150/12.50mg can affect kidney function in several ways. Irbesartan reduces intraglomerular pressure (beneficial in diabetic nephropathy but causing a modest creatinine rise). HCTZ reduces blood volume, which in susceptible patients (elderly, CKD, dehydrated) can reduce renal perfusion and raise creatinine further. The combination of ARB + diuretic can precipitate acute kidney injury in volume-depleted patients or those with underlying renovascular disease ('triple whammy' with NSAIDs). Renal function (creatinine, eGFR) and electrolytes (potassium, Sodiumium) should be checked before initiating Irovel H and 1–2 weeks after, then every 3–6 months. Irovel H is contraindicated in severe renal impairment.
Can Irovel H 150/12.5mg lower potassium too much?
Irovel H 150/12.50mg has opposing effects on potassium. HCTZ promotes potassium excretion (causing hypokalaemia in some patients), while irbesartan reduces aldosterone-mediated potassium loss (tending to raise potassium). In most patients, these effects partially cancel out, resulting in a relatively potassium-neutral combination — an advantage over HCTZ alone. However, some patients may experience either hypokalaemia (HCTZ dominates, especially at higher HCTZ doses) or hyperkalaemia (irbesartan dominates, especially in CKD or with concurrent potassium-sparing diuretics). Serum potassium should be monitored at baseline and regularly during therapy. Potassium supplements or potassium-rich diet changes should only be made under physician guidance.
How does Irovel H 150/12.5mg compare to taking irbesartan and HCTZ as separate tablets?
Irovel H 150/12.50mg provides the same irbesartan 150mg and HCTZ 12.5mg doses as taking them as separate tablets, but in a single combined tablet. The clinical benefits of the fixed-dose combination include improved adherence (one tablet instead of two), reduced pill burden — important for hypertensive patients often taking multiple medications — and typically lower combined cost than two separate branded products. Bioequivalence studies confirm the fixed-dose combination delivers the same drug exposure as separate tablets. Irovel H is recommended for patients already stable on this dose combination who want the convenience of a single daily tablet.
Is Irovel H 150/12.5mg suitable for patients with diabetes?
Irovel H 150/12.50mg is suitable for diabetic hypertensive patients with some nuances. Irbesartan provides renal protection beneficial in diabetic nephropathy. HCTZ in thiazide doses (12.5mg) has minimal adverse metabolic effects on glucose and lipids — the metabolic concerns with thiazides are mainly dose-related and more significant at 25–50mg. At 12.5mg, HCTZ is generally metabolically neutral. For diabetic patients with established nephropathy and overt proteinuria, Irovel H provides convenient blood pressure control with the irbesartan renal protection component. Monitor fasting glucose, HbA1c, uric acid, and serum potassium during therapy. Avoid Irovel H in patients with severe diabetic renal impairment (eGFR <30 ml/min).
Where can I buy Irovel H 150/12.5mg affordably?
Irovel H 150/12.50mg is available at AllDayChemist, a licensed international pharmacy operating since 2002, serving the USA, UK, Australia, and most of the countries. AllDayChemist sources authentic irbesartan/HCTZ combination tablets from licensed manufacturers at competitive prices — particularly affordable compared to branded Avalide 150/12.5mg at US retail pharmacies. For patients on stable long-term combination antihypertensive therapy, AllDayChemist provides reliable supply with worldwide tracked delivery and discreet packaging. Irovel H is a prescription medication requiring regular blood pressure and electrolyte monitoring — ensure ongoing medical supervision is in place before ordering.
Does AllDayChemist ship Irovel H 150/12.5mg to Australia?
Yes, AllDayChemist ships Irovel H 150/12.50mg to Australia, USA, UK, and most of the countries worldwide. Australian customers can access affordable irbesartan/HCTZ combination tablets at prices competitive with local pharmacy options for generic or branded irbesartan+HCTZ. AllDayChemist provides worldwide tracked delivery and discreet packaging for all orders. TGA guidelines for importing personal-use quantities of prescription combination antihypertensives from licensed international pharmacies should be reviewed before ordering. AllDayChemist's customer service team can assist Australian customers with any queries about ordering and receiving Irovel H 150/12.50mg.
What are the side effects of Irovel H 150/12.5mg?
Side effects of Irovel H 150/12.50mg reflect both components: from irbesartan — dizziness, headache, fatigue, mild hyperkalaemia, and (rarely) angioedema; from HCTZ — increased urination (particularly early in therapy), mild electrolyte disturbances (hyponatraemia, hypokalaemia — mitigated by irbesartan's potassium-sparing effect), hyperuricaemia (gout risk), photosensitivity, and mild glucose elevation. Dehydration and hypotension can occur, particularly in hot weather or during acute illness. The combination is not associated with ACE inhibitor-type cough. Rare serious effects include severe electrolyte disturbances, acute kidney injury in volume depletion, and significant hyponatraemia in elderly patients. Regular blood tests for electrolytes and renal function are recommended.
Can Irovel H 150/12.5mg cause dehydration?
Yes. The HCTZ component of Irovel H 150/12.50mg promotes urine output, which can cause mild dehydration — particularly in hot weather, during physical exertion, or concurrent illness with fever, vomiting, or diarrhoea. Dehydration reduces blood volume and can lower blood pressure excessively, causing dizziness, light-headedness, or fainting. The 'sick day rule' applies: during acute illness causing significant fluid losses or reduced intake, Irovel H should be temporarily held until recovery and fluid status is restored. Ensure adequate hydration (6–8 glasses of water daily) during normal conditions. Report significant dizziness on standing, reduced urine output, or dry mouth to your doctor during Irovel H therapy.
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