Available Dosages
| SKU: | 550 |
|---|---|
| Generic For: | Isosorb Mono |
| Active Ingredient: | Isosorbide Mononitrate |
| Manufacturer: | Abbott Pharmaceticals, India |
Buy Ismo 20mg (Isosorbide Mononitrate) Online
Ismo 20 mg contains Isosorbide mononitrate, a nitrate class of drug that is efficient in treating Angina Pectoris or at least reducing the occurrence of this problem. The problem of angina pain is most common in patients with certain heart problems like coronary artery disease.
Angina pain is chest pain that often arises due to obstructions in the coronary arteries.
Ismo 20 must not be used I the following conditions:
— Acute circulatory failure
— Severe anaemia
— Marked hypotension
— Cardiogenic shock
— Severe hypovolaemia
— Hypersensitivity to Isosorbide mononitrate, other nitrate compounds, or any ingredients
Ismo tablets may only be taken with caution in the following cases:
— Aortic or mitral stenosis
— Hypertrophic obstructive cardiomyopathy, pericardial tamponade, and constrictive pericarditis
— Susceptibility to orthostatic circulatory dysregulation
— Disorders associated with increased intracranial pressure
Isosorbide mononitrate is not suitable for treating acute myocardial infarction or angina pectoris. Safety, effectiveness, and dosage of Isosorbide-5-nitrate in children have not been established. Patients with rare hereditary problems of glucose-galactose malabsorption should not take Ismo 20 mg.
Concomitant use of other vasodilators, antihypertensive agents, beta-blockers, ACE inhibitors, diuretics, tricyclic anti-depressants, neuroleptics, calcium antagonists, and alcohol can potentiate the antihypertensive effect of Ismo. This particularly applies to the concomitant use of erectile dysfunction drugs such as sildenafil, tadalafil, and vardenafil.
For special precautionary reasons, the isosorbide mononitrate drug should only be taken during pregnancy on the instructions of a doctor, as there is no adequate report on the use of Ismo 20 mg in pregnant women.
There is insufficient experience with use in lactating women, and whether the medicine passes into breast milk is unknown. If Ismo is taken during breastfeeding, close monitoring is required for possible drug effects in the infant.
During the initial days of the treatment, a headache may occur, which most resolves after a few days of constant intake. A significant drop in blood pressure with worsening angina pectoris symptoms has been observed. Severe hypotensive responses, including nausea, restlessness, vomiting, pallor, and hyperhidrosis, have been reported for organic nitrates. Please talk to your doctor if any of these become troublesome or if you develop other side effects that persist for longer.
The standard dose of Ismo 20 mg is one tablet twice daily, which might be increased to one tablet daily if the individual requirement is higher. To prevent or minimize nitrate headaches, it is recommended that the dose is reduced to half a tablet twice daily for the initial two days and then increased to one tablet two times a day for the next two days. Afterwards, the treatment regimen can be maintained at this level or increased, if necessary, to one tablet thrice daily. Treatment with Ismo 20 mg is normally long-term therapy. The tablet should be swallowed uncrushed or unchewed with plenty of water. If needed, one tablet can be taken shortly before going to sleep. It is important to take the drug as instructed by your doctor. The sudden discontinuance of medicine can cause undesirable reactions. So, it is necessary that before stopping the drug intake, you should always consult a physician first.
Generally, this tablet is advised to be taken once a day. Always take the dose as prescribed by the physician. It is very important to consume medicine timely. Various factors are observed before prescribing a drug; thus, your doctor will prescribe the best suitable dose for you. Dosage can be adjusted depending on the patient’s severity of the condition.
What is Ismo 20mg used for?
Ismo 20mg contains Isosorbide Mononitrate (ISMN) 20mg, a long-acting organic nitrate used to prevent angina pectoris (chest pain caused by coronary artery disease). Unlike sublingual nitroglycerin, Ismo 20mg is not for acute attacks — it works prophylactically by dilating coronary and peripheral vessels, reducing the heart's workload and frequency of angina epiSodiumes when taken regularly.
How does Isosorbide Mononitrate in Ismo 20mg work?
Isosorbide Mononitrate is an active metabolite of Isosorbide Dinitrate. It releases nitric oxide in smooth muscle cells, activating guanylate cyclase, which produces cGMP — causing venous and arterial dilation. Venous dilation reduces preload (blood returning to the heart), and arterial dilation reduces afterload. Together, these effects decrease myocardial oxygen demand, preventing ischaemia and angina.
How should Ismo 20mg be taken?
Ismo 20mg immediate-release tablets are typically taken twice daily. To avoid nitrate tolerance, an eccentric dosing schedule is recommended: doses are taken at 8am and 3pm (or 7–8 hours apart), leaving a nitrate-free interval of about 14 hours overnight. This prevents the body from becoming desensitised to the medication. Never take two doses within six hours of each other.
Why is there a nitrate-free interval with Ismo 20mg?
Continuous nitrate exposure causes tolerance — the vessels stop responding to the drug, losing its antianginal benefit. The eccentric dosing schedule (e.g., 8am and 3pm) ensures a 14-hour nitrate-free window overnight, during which the vascular system resets its sensitivity to nitrates. This is essential for maintaining Ismo 20mg's effectiveness. Sustained-release formulations handle this issue differently.
Can Ismo 20mg be used during pregnancy?
There is limited safety data for Isosorbide Mononitrate in pregnancy. It is not routinely recommended unless the cardiovascular risk of untreated angina clearly outweighs the fetal risk. Nitrates cross the placenta. If coronary artery disease requires treatment during pregnancy, discuss with your cardiologist and obstetrician, who will evaluate safer alternatives or decide if ISMN is absolutely necessary.
Is Ismo 20mg safe with erectile dysfunction medications?
No. Combining Ismo 20mg with PDE-5 inhibitors (sildenafil/Viagra, tadalafil/Cialis, vardenafil) is absolutely contraindicated. Both drugs lower blood pressure via different mechanisms, and the combination can cause severe, potentially fatal hypotension. This contraindication is listed as absolute. Inform all prescribers and pharmacists about your Ismo 20mg use before any new prescription is given.
How does Ismo 20mg compare to Imdur 20mg?
Ismo 20mg and Imdur (in its 20mg tablet form) both contain Isosorbide Mononitrate 20mg. Imdur is more commonly available in 30mg or 60mg sustained-release formulations. Ismo is the immediate-release form requiring twice-daily eccentric dosing. Both are effective antianginals. The choice between immediate-release and sustained-release formulations depends on patient adherence preference and prescriber recommendation.
Is Ismo 20mg a generic alternative to branded Isosorbide Mononitrate?
Yes. Ismo 20mg is a quality-assured generic Isosorbide Mononitrate 20mg tablet. The originator brands such as Imdur and Ismo (branded in some markets) are available at premium prices. The generic equivalent provides identical antianginal protection. AllDayChemist offers Ismo 20mg at significantly lower prices than Western retail antianginals, making preventive angina therapy accessible.
Can I buy Ismo 20mg at AllDayChemist?
Yes. Ismo 20mg is available at AllDayChemist with worldwide shipping to the USA, UK, Australia, and 200+ countries. AllDayChemist has operated since 2002 with authentic, manufacturer-sourced medicines. Orders arrive in discreet, plain packaging with tracking. Free shipping is available on qualifying orders.
Why buy Ismo 20mg from AllDayChemist?
AllDayChemist provides Ismo 20mg at competitive prices that are substantially lower than comparable nitrate therapy in Western pharmacies. With 20+ years of international service since 2002 and customers in 200+ countries, AllDayChemist delivers authentic cardiac medications reliably. Discreet packaging, free worldwide shipping on qualifying orders, and responsive customer support complete the value proposition.
What side effects does Ismo 20mg cause?
The most common side effect of Ismo 20mg is headache — caused by cerebral venous dilation. This often diminishes after one to two weeks as tolerance develops (paradoxically, headache tolerance develops faster than antianginal tolerance). Other effects include dizziness, flushing, and orthostatic hypotension. Severe headache can be managed with paracetamol. Starting at a lower dose and titrating up may reduce initial headache severity.
What precautions are important when taking Ismo 20mg?
Never use with PDE-5 inhibitors — the interaction is life-threatening. Rise slowly from seated positions due to postural hypotension risk. Do not stop Ismo 20mg abruptly without medical advice as rebound angina can occur. Avoid alcohol as it amplifies hypotensive effects. Maintain the eccentric dosing schedule religiously to prevent tolerance. Keep sublingual glyceryl trinitrate (GTN) available for breakthrough angina attacks.
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