Seretide Accuhaler 500 mcg / 50 mcg (60 Doses)
Upto 9% OFF
Fluticasone and Salmeterol 500mcg/50mcg
$50.00 - $55.00
Available Dosages
| SKU: | 922 |
|---|---|
| Generic For: | Advair Accuhaler |
| Active Ingredient: | Fluticasone and Salmeterol Inhalation Powder, pre-dispensed BP |
| Manufacturer: | GSK, France |
Buy Seretide Accuhaler 500 mcg / 50 mcg (60 Doses) Online
Seretide Accuhaler 500 mcg/50 mcg is a widely prescribed combination inhalation therapy used for the long-term management of asthma and chronic obstructive pulmonary disease (COPD). Each dose delivers two powerful active ingredients — Fluticasone Propionate (500 mcg) and Salmeterol Xinafoate (50 mcg) — in a convenient, breath-activated dry powder inhaler (DPI) format.
Designed for twice-daily use, Seretide Accuhaler offers dual-action respiratory relief by simultaneously opening the airways and reducing inflammation, helping patients breathe more freely and live more comfortably. Available in a 60-dose Accuhaler device, this medication is a trusted staple in respiratory care worldwide and is sold at AllDayChemist at a competitive, affordable price.
What Is Seretide Accuhaler Used For?
Seretide Accuhaler 500 mcg/50 mcg is primarily indicated for:
- Asthma management in adults and adolescents (12 years and above) whose condition is not adequately controlled by inhaled corticosteroids or short-acting bronchodilators alone
- Chronic Obstructive Pulmonary Disease (COPD), including chronic bronchitis and emphysema, aims to reduce the frequency and severity of exacerbations
- Maintenance therapy for patients who require regular bronchodilation combined with anti-inflammatory treatment
- Prevention of exercise-induced bronchoconstriction in eligible patients
Important: It is not intended as a rescue inhaler for sudden breathlessness. For acute asthma attacks, a separate fast-acting bronchodilator (such as Salbutamol/Albuterol) should be kept on hand.
Manufacturer
Seretide Accuhaler 500 mcg/50 mcg is manufactured by GlaxoSmithKline (GSK), France, one of the world's leading pharmaceutical and healthcare companies with decades of expertise in respiratory medicine.
Working Mechanism of the Active Components
Fluticasone Propionate (Corticosteroid):
Fluticasone is a synthetic corticosteroid that exerts potent local anti-inflammatory action within the airways. It works by inhibiting the release of inflammatory mediators, such as cytokines, histamine, and leukotrienes — from immune cells, including mast cells and eosinophils. Over time, this reduces airway swelling, mucus production, and bronchial hyperresponsiveness, resulting in fewer asthma symptoms and improved lung function.
Salmeterol Xinafoate (Long-Acting Beta-2 Agonist – LABA):
Salmeterol is a selective long-acting beta-2 adrenoceptor agonist (LABA). It binds to beta-2 receptors on smooth muscle cells lining the bronchial walls, triggering relaxation of the constricted airway muscles. This bronchodilatory effect begins within 10–20 minutes of inhalation and lasts for approximately 12 hours, making it ideal for twice-daily dosing. Salmeterol also helps prevent the release of bronchoconstricting substances from mast cells.
Together, these two ingredients address both the inflammatory and obstructive components of airway disease, offering more comprehensive control than either agent alone.
Clinical Uses of Fluticasone and Salmeterol
Beyond standard asthma and COPD management, the combination of Fluticasone and Salmeterol has demonstrated clinical benefit in several scenarios:
- Step-up therapy for patients whose asthma is uncontrolled on low-to-medium dose inhaled corticosteroids alone
- Reduction of COPD exacerbations and hospitalizations in patients with severe airflow limitation
- Nocturnal asthma — improving nighttime symptoms and sleep quality
- Exercise-induced bronchoconstriction prophylaxis, when used regularly
- Eosinophilic airway inflammation — Fluticasone specifically targets eosinophil activity, a hallmark of allergic asthma
- Adjunctive use in patients transitioning away from oral corticosteroids, as Fluticasone provides significant systemic steroid-sparing effects
Clinical trials have confirmed that the Fluticasone/Salmeterol combination significantly improves FEV1 (forced expiratory volume), reduces the need for rescue inhalers, and enhances overall quality of life in both asthma and COPD patients.
Key Benefits of Seretide Accuhaler 500 mcg/50 mcg
- Dual-action formula: Combines a corticosteroid and a LABA for comprehensive airway control
- Long-lasting bronchodilation: Salmeterol provides up to 12 hours of airway opening, supporting convenient twice-daily dosing
- Reduced inflammation: Fluticasone tackles the root cause of asthma — chronic airway inflammation
- Convenient Accuhaler device: Breath-activated dry powder inhaler — no coordination required between pressing and inhaling
- Fewer rescue inhaler uses: Regular use reduces dependence on short-acting bronchodilators.
- Improved lung function: Clinically proven to increase FEV1 and peak expiratory flow rate (PEFR)
- Better quality of life: Fewer nighttime awakenings, reduced symptom days, and improved exercise tolerance
- Consistent dosing: Each of the 60 pre-measured doses is sealed individually within the Accuhaler blister strip, ensuring accuracy and freshness
Brand vs Generic Differences – Is Seretide Accuhaler the Same as Advair Diskus?
Yes — Seretide Accuhaler is the international brand equivalent of Advair Diskus, which is the brand name used primarily in the United States. GlaxoSmithKline manufactures both and contains identical active ingredients: Fluticasone Propionate and Salmeterol Xinafoate, in the same strengths and the same Accuhaler delivery device.
|
Feature |
Seretide Accuhaler |
Advair Diskus |
|
Brand Name Region |
International (Europe, Asia, etc.) |
USA |
|
Active Ingredients |
Fluticasone + Salmeterol |
Fluticasone + Salmeterol |
|
Manufacturer |
GSK, France |
GSK, USA |
|
Delivery Device |
Diskus DPI |
Diskus DPI |
|
Price |
More affordable |
Higher cost |
Generic versions containing Fluticasone and Salmeterol are also available and contain the same active ingredients in equivalent doses. The main difference between brand and generic is the price — generics offer substantial savings while maintaining therapeutic equivalence.
Strengths and Alternative Options Available on AllDayChemist
AllDayChemist offers Seretide Accuhaler in multiple strengths to match varying levels of disease severity:
- Seretide Accuhaler 100 mcg/50 mcg — Suitable for mild-to-moderate asthma
- Seretide Accuhaler 250 mcg/50 mcg — For moderate asthma requiring stepped-up therapy
- Seretide Accuhaler 500 mcg/50 mcg — For severe asthma or COPD with significant airflow limitation
Similar products are also available on AllDayChemist:
- Advair Diskus (US brand equivalent)
- Advair Rotacaps (capsule-based inhaler format)
- Triohale (triple combination inhaler for advanced COPD)
- Duova Inhaler / Rotacaps (Tiotropium + Formoterol combination for COPD)
- Pulmicort Rotacaps (Budesonide alone, for patients needing only an ICS)
- Serevent (Salmeterol alone, for patients not requiring a steroid component)
Let your physician determine the most appropriate strength and formulation based on your spirometry results, symptom frequency, and treatment history.
Precautions, Drug Interactions, and Warnings
Precautions:
- Do not use as a rescue inhaler—always keep a short-acting bronchodilator available for acute episodes.
- Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
- Use with caution if you have a history of cardiovascular disease, hypertension, diabetes, thyroid disorders, or seizures/epilepsy.
- Not recommended for patients with known hypersensitivity to Fluticasone, Salmeterol, or lactose (the carrier in the powder)
- Paradoxical bronchospasm (worsening wheeze immediately after use) has been reported — discontinue use and seek medical attention if this occurs.
Drug Interactions:
- Beta-blockers (e.g., atenolol, propranolol): May reduce the bronchodilatory effect of Salmeterol and can trigger bronchospasm
- Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir, boceprevir, telithromycin): May increase systemic exposure to Fluticasone, raising the risk of corticosteroid side effects.
- Diuretics and xanthines (e.g., theophylline): Combined use may increase the risk of hypokalemia (low potassium)
- MAO inhibitors and tricyclic antidepressants: May potentiate the cardiovascular effects of Salmeterol
- Sympathomimetics (e.g., adrenaline/epinephrine): Increased risk of cardiovascular side effects
- Digitalis glycosides: Hypokalemia may increase the risk of cardiac arrhythmias
Warnings:
- Long-term, high-dose inhaled corticosteroids may reduce bone mineral density; adequate calcium and vitamin D intake is advisable.
- Monitor for signs of adrenal suppression with prolonged use, especially in children.
- Avoid abrupt discontinuation — taper use under medical supervision if stopping long-term therapy.
- In case of overdose (palpitations, tremors, headache, elevated blood pressure), contact a healthcare provider or poison control center immediately.
Side Effects of Fluticasone and Salmeterol
Common side effects:
- Headache
- Mild tremors or shakiness
- Palpitations (rapid or irregular heartbeat)
- Throat irritation or hoarseness
- Oral thrush (candidiasis) — rinsing the mouth after use reduces this risk
- Nasal congestion or nosebleeds
- Nausea
Less common side effects:
- Dizziness or lightheadedness
- Muscle cramps
- Ankle swelling (edema)
- Restlessness or nervousness
- Sweating and fatigue
- Urticaria (hives) or skin rash
Rare but serious side effects:
- Paradoxical bronchospasm (immediate worsening of breathing after inhalation)
- Hypokalemia (low blood potassium levels)
- Hyperglycemia (elevated blood sugar, particularly relevant in diabetic patients)
- Adrenal suppression with long-term high-dose use
- Allergic reactions, including angioedema
If any severe or persistent side effects occur, discontinue use and consult a doctor immediately.
Why Buy Seretide Accuhaler 500 mcg/50 mcg from AllDayChemist?
AllDayChemist has been a trusted online pharmacy for over two decades, serving customers worldwide with genuine, high-quality medications at highly competitive prices. Here's why thousands of patients choose AllDayChemist:
- Authenticity guaranteed: All products are sourced directly from licensed manufacturers and authorized distributors — 100% genuine medications every time
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- Multiple strength options: Choose from 100 mcg/50 mcg, 250 mcg/50 mcg, and 500 mcg/50 mcg to suit your prescribed therapy
- Secure payment options: Accepts eCheck and other secure payment methods for a smooth, safe checkout experience
- Discreet and reliable shipping: Orders are carefully packaged and shipped with tracking, ensuring your medication arrives safely and on time
- Outstanding customer service: Rated 4.9/5 based on over 38,000 verified customer reviews, with a dedicated support team available to assist you
- Easy reordering: Create an account to track your order history and reorder your regular medications with just a few clicks
- New customer discount: Sign up and receive an instant 10% discount coupon on your first order
Managing chronic respiratory conditions like asthma and COPD requires consistent, uninterrupted access to your medication. AllDayChemist makes that easy — order Seretide Accuhaler 500 mcg/50 mcg online today and take control of your respiratory health.
How to Use Fluticasone and Salmeterol – Dosage, Administration, and Storage
Dosage:
- Adults and adolescents (12 years and above): One inhalation of Seretide Accuhaler 500 mcg/50 mcg twice daily (morning and evening), approximately 12 hours apart
- Children (4–11 years): Lower-strength formulations (100 mcg/50 mcg) are typically used; the 500 mcg/50 mcg strength is generally reserved for adults
- Do not exceed two inhalations per day unless directed by your physician.
How to Use the Accuhaler:
- Hold the Accuhaler in a horizontal position and slide the thumb grip away from you until it clicks open
- Slide the lever away from you until it clicks — this loads one dose
- Breathe out gently (away from the inhaler)
- Place the mouthpiece between your lips and inhale steadily and deeply
- Hold your breath for 10 seconds, then exhale slowly
- Close the Accuhaler by sliding the thumb grip back
- Rinse your mouth with water after each use to prevent oral candidiasis (thrush)
Storage:
- Store below 30°C (86°F) in a dry place, away from direct sunlight and heat
- Keep the Accuhaler closed when not in use
- Do not refrigerate or freeze
- Keep out of reach of children
- Check the dose counter regularly and replace when empty
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