Available Dosages
| SKU: | 830 |
|---|---|
| Generic For: | Prometrium |
| Active Ingredient: | Progesterone |
| Manufacturer: | Sun Pharma, India |
Buy Susten 100 mg (Progesterone) for Women's Health
Susten 100mg is a prescription oral softgel capsule containing Micronised Progesterone 100mg, a bioidentical form of the naturally occurring female sex hormone progesterone. Susten 100mg is used for luteal phase support in assisted reproductive technology (ART) cycles, as part of hormone replacement therapy (HRT) in menopausal women, for the management of secondary amenorrhoea, and for the prevention of preterm birth in women with a history of spontaneous preterm delivery. The micronisation of progesterone particles to a very fine size is critical to its oral bioavailability — conventional progesterone is poorly absorbed orally, but micronised progesterone achieves clinically meaningful serum levels, delivering the physiological and therapeutic effects of progesterone through the oral route with a tolerability profile superior to that of synthetic progestins.
What is Susten 100mg?
Susten 100mg is a soft gelatin capsule containing Micronised Progesterone 100mg dispersed in an arachis oil (groundnut oil) or similar excipient base. Progesterone is the primary endogenous progestogen produced by the corpus luteum following ovulation and by the placenta during pregnancy. Micronised Progesterone 100mg is the lower dose in the Susten range, used primarily for luteal phase supplementation in IVF and other ART protocols where controlled ovarian stimulation suppresses normal corpus luteum function, and for initiating hormone replacement therapy in perimenopausal women requiring progesterone for endometrial protection alongside oestrogen. The capsule may be taken orally or administered vaginally — vaginal administration bypasses hepatic first-pass metabolism. It achieves higher uterine progesterone concentrations with lower systemic exposure, a route particularly favoured in IVF luteal support protocols.
Manufacturer: Susten 100mg is manufactured by Sun Pharma (Sun Pharmaceutical Industries Ltd.), India’s largest pharmaceutical company with a market-leading women’s health portfolio, including the Susten brand of micronised progesterone, distributed across domestic and international reproductive medicine markets.
Key Ingredients of Susten 100mg and Their Working Process
Micronised Progesterone 100mg is bioidentical to the progesterone produced naturally by the ovary — identical in molecular structure to endogenous progesterone, unlike synthetic progestins (such as medroxyprogesterone acetate or norethisterone) which have structural modifications that alter their receptor binding profile and produce additional androgenic, glucocorticoid, or other off-target hormonal effects. After oral ingestion, micronised progesterone is absorbed through the intestinal mucosa. It undergoes first-pass hepatic metabolism, producing metabolites, including allopregnanolone — a neurosteroid that positively modulates GABA-A receptors — which accounts for the sedative properties of oral micronised progesterone. The intact progesterone that enters systemic circulation binds to progesterone receptors (PR-A and PR-B) in the endometrium, myometrium, cervix, and breast tissue, producing its key biological effects.
In the uterine endometrium, progesterone binding converts oestrogen-stimulated proliferative endometrium to secretory endometrium — a transformation essential for embryo implantation and support of early pregnancy. This endometrial transformation underlies progesterone’s role in luteal phase support and its protective effect against oestrogen-induced endometrial hyperplasia in HRT. In the myometrium, progesterone reduces the sensitivity of uterine smooth muscle to oxytocin and prostaglandins, suppressing uterine contractility — the mechanism underlying its use in preterm birth prevention. The neurosteroid metabolite allopregnanolone acts on GABA-A receptors in the central nervous system, producing the calming and sedative effects associated with the luteal phase and with oral progesterone therapy, and is also being investigated for therapeutic applications in conditions ranging from postpartum depression to epilepsy.
Clinical Uses of Micronised Progesterone 100mg
Susten 100mg has several well-defined clinical indications in reproductive medicine, gynaecology, and menopause management. In assisted reproductive technology, it is the standard agent for luteal phase support — the supplementation of progesterone following oocyte retrieval and embryo transfer in IVF cycles, where the controlled ovarian stimulation protocol suppresses the corpus luteum, creating a progesterone-deficient state that would otherwise prevent embryo implantation. Used vaginally or orally from the day of embryo transfer, progesterone supplementation recreates the hormonal environment needed for implantation and early placental function until the placenta takes over endogenous progesterone production at approximately 10 weeks of gestation.
In hormone replacement therapy for perimenopausal and postmenopausal women, Susten 100mg is used in combination with oestrogen therapy to protect the endometrium from the proliferative effects of unopposed oestrogen, which carries a risk of endometrial hyperplasia and carcinoma. Bioidentical micronised progesterone is preferred over synthetic progestins in HRT for its more favourable safety profile — particularly regarding breast cancer risk, which is lower with micronised progesterone than with synthetic progestins in observational data. Susten 100mg is also used for secondary amenorrhoea (absence of menstrual periods), where a short course can induce withdrawal bleeding to confirm adequate oestrogen priming and assess the integrity of the endometrium and outflow tract.
Comparing Susten 100mg and Prometrium 100mg: Brand vs Generic Differences
Susten 100mg and Prometrium 100mg both contain progesterone 100mg and are prescribed for hormone imbalance, menstrual disorders, infertility support, and pregnancy-related progesterone supplementation. Prometrium is a branded progesterone medicine, while Susten is a generic alternative that is generally more affordable and widely available in India. Both medicines work in the same way by restoring progesterone levels in the body and are considered therapeutically similar when used as directed. However, they may differ in manufacturer, capsule shell composition, inactive ingredients, pricing, and packaging. Some patients may experience slight differences in absorption, digestion, or side effects such as drowsiness or bloating due to formulation variations. Doctors may choose one based on patient preference, cost, or availability. These medicines should always be used under proper medical supervision, especially during fertility or pregnancy treatment.
Related strengths and products: For women requiring higher progesterone doses — including those with inadequate implantation support or those in high-dose luteal support protocols — Susten 200mg provides double the progesterone content per capsule, reducing the daily capsule burden and enabling convenient dosing at 400 to 600mg daily where required.
Key Benefits of Susten 100mg
Susten 100mg delivers bioidentical micronised progesterone — molecularly identical to the body’s own progesterone — offering a more physiologically natural hormonal effect than synthetic progestins and a more favourable tolerability profile in terms of androgenic, metabolic, and cardiovascular side effects. Its dual route of administration flexibility — oral or vaginal — allows clinicians and patients to optimise delivery based on the clinical context: vaginal administration provides superior uterine tissue progesterone concentrations for ART luteal support, while oral administration is more convenient for HRT endometrial protection. The sedative properties of oral micronised progesterone (mediated by allopregnanolone) can be an advantage for women experiencing sleep disturbances around the perimenopause when used as an evening HRT dose. In ART, its role in enabling successful embryo implantation and supporting early pregnancy represents one of the most clinically significant applications of any pharmaceutical agent in reproductive medicine.
Usage warnings and precautionary advice for using Micronised Progesterone 100mg
Susten 100mg is contraindicated in patients with known or suspected progesterone-sensitive malignancies, undiagnosed vaginal bleeding, active thromboembolic disease or a history of progesterone-associated thromboembolism, and severe hepatic impairment. Patients with peanut or arachis oil allergy must not use the standard formulation. Progesterone therapy should be used with caution in patients with a history of depression — while micronised progesterone has a more favourable neuropsychiatric profile than synthetic progestins, mood effects can still occur in sensitive individuals. The sedative effect of oral micronised progesterone requires caution regarding driving and operating machinery within several hours of dosing — bedtime administration is strongly recommended to avoid daytime impairment. Progesterone affects glucose metabolism; diabetic patients should monitor blood glucose more closely during initiation of therapy. In ART protocols, the specific dose, route, timing, and duration of progesterone supplementation should be strictly adhered to as prescribed by the fertility specialist.
Side effects of Micronised Progesterone 100mg
Susten 100mg is generally well tolerated, particularly compared to synthetic progestins. The most commonly reported side effect of oral micronised progesterone is sedation and drowsiness, which occurs within 1 to 3 hours of oral dosing and is why evening or bedtime administration is routinely recommended. Dizziness and, in some women, euphoria or mood changes are occasionally noted. Breast tenderness is a common class effect of progestogen therapy and may occur during the progesterone phase of a cycle. Irregular spotting or breakthrough bleeding can occur, particularly during the initial months of HRT therapy. Vaginal administration is generally better tolerated systemically but may cause local effects, including vaginal discharge, irritation, or yeast overgrowth. Headache is occasionally reported. Thromboembolic events are a class concern for all sex hormone therapies, though observational data suggest micronised progesterone has a lower venous thromboembolism risk than many synthetic progestins.
Benefits of Buying Susten 100mg Online
AllDayChemist provides Susten 100mg at highly competitive prices with reliable international delivery — an important access channel for women undergoing IVF who require consistent and affordable progesterone supplementation across a treatment cycle, and for those on long-term HRT who benefit from the cost savings of ordering through AllDayChemist compared to local pharmacy pricing. Our discreet packaging and secure checkout help respect patient privacy in sensitive areas of women’s health.
Proper dosage and usage guide of Micronised Progesterone 100mg
For oral use, Susten 100mg capsules should be swallowed whole with water. For vaginal use, the capsule is inserted high into the vagina using a clean finger or an applicator, after which the patient should remain lying down for at least 30 minutes. For ART luteal phase support: typically 200 to 600mg daily vaginally (or orally as directed), starting on the day of embryo transfer and continuing for 8 to 12 weeks under physician guidance. For HRT endometrial protection: 100mg orally at bedtime for 12 to 14 consecutive days per month in a cyclic regimen with oestrogen, or as directed for continuous use. For secondary amenorrhoea: 100 to 200mg orally at bedtime for 10 to 12 days to induce a withdrawal bleed. Evening or bedtime administration of the oral dose is recommended to take advantage of progesterone’s sedative properties and minimise daytime drowsiness. Store below 25°C in a dry, dark place; avoid storage in warm or humid environments.
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