Available Dosages
| SKU: | 830 |
|---|---|
| Generic For: | Prometrium |
| Active Ingredient: | Progesterone |
| Manufacturer: | Sun Pharma, India |
Buy Susten 100 mg (Progesterone) for Women's Health
Susten 100mg is a prescription oral softgel capsule containing Micronised Progesterone 100mg, a bioidentical form of the naturally occurring female sex hormone progesterone. Susten 100mg is used for luteal phase support in assisted reproductive technology (ART) cycles, as part of hormone replacement therapy (HRT) in menopausal women, for the management of secondary amenorrhoea, and for the prevention of preterm birth in women with a history of spontaneous preterm delivery. The micronisation of progesterone particles to a very fine size is critical to its oral bioavailability — conventional progesterone is poorly absorbed orally, but micronised progesterone achieves clinically meaningful serum levels, delivering the physiological and therapeutic effects of progesterone through the oral route with a tolerability profile superior to that of synthetic progestins.
What is Susten 100mg?
Susten 100mg is a soft gelatin capsule containing Micronised Progesterone 100mg dispersed in an arachis oil (groundnut oil) or similar excipient base. Progesterone is the primary endogenous progestogen produced by the corpus luteum following ovulation and by the placenta during pregnancy. Micronised Progesterone 100mg is the lower dose in the Susten range, used primarily for luteal phase supplementation in IVF and other ART protocols where controlled ovarian stimulation suppresses normal corpus luteum function, and for initiating hormone replacement therapy in perimenopausal women requiring progesterone for endometrial protection alongside oestrogen. The capsule may be taken orally or administered vaginally — vaginal administration bypasses hepatic first-pass metabolism. It achieves higher uterine progesterone concentrations with lower systemic exposure, a route particularly favoured in IVF luteal support protocols.
Manufacturer: Susten 100mg is manufactured by Sun Pharma (Sun Pharmaceutical Industries Ltd.), India’s largest pharmaceutical company with a market-leading women’s health portfolio, including the Susten brand of micronised progesterone, distributed across domestic and international reproductive medicine markets.
Key Ingredients of Susten 100mg and Their Working Process
Micronised Progesterone 100mg is bioidentical to the progesterone produced naturally by the ovary — identical in molecular structure to endogenous progesterone, unlike synthetic progestins (such as medroxyprogesterone acetate or norethisterone) which have structural modifications that alter their receptor binding profile and produce additional androgenic, glucocorticoid, or other off-target hormonal effects. After oral ingestion, micronised progesterone is absorbed through the intestinal mucosa. It undergoes first-pass hepatic metabolism, producing metabolites, including allopregnanolone — a neurosteroid that positively modulates GABA-A receptors — which accounts for the sedative properties of oral micronised progesterone. The intact progesterone that enters systemic circulation binds to progesterone receptors (PR-A and PR-B) in the endometrium, myometrium, cervix, and breast tissue, producing its key biological effects.
In the uterine endometrium, progesterone binding converts oestrogen-stimulated proliferative endometrium to secretory endometrium — a transformation essential for embryo implantation and support of early pregnancy. This endometrial transformation underlies progesterone’s role in luteal phase support and its protective effect against oestrogen-induced endometrial hyperplasia in HRT. In the myometrium, progesterone reduces the sensitivity of uterine smooth muscle to oxytocin and prostaglandins, suppressing uterine contractility — the mechanism underlying its use in preterm birth prevention. The neurosteroid metabolite allopregnanolone acts on GABA-A receptors in the central nervous system, producing the calming and sedative effects associated with the luteal phase and with oral progesterone therapy, and is also being investigated for therapeutic applications in conditions ranging from postpartum depression to epilepsy.
Clinical Uses of Micronised Progesterone 100mg
Susten 100mg has several well-defined clinical indications in reproductive medicine, gynaecology, and menopause management. In assisted reproductive technology, it is the standard agent for luteal phase support — the supplementation of progesterone following oocyte retrieval and embryo transfer in IVF cycles, where the controlled ovarian stimulation protocol suppresses the corpus luteum, creating a progesterone-deficient state that would otherwise prevent embryo implantation. Used vaginally or orally from the day of embryo transfer, progesterone supplementation recreates the hormonal environment needed for implantation and early placental function until the placenta takes over endogenous progesterone production at approximately 10 weeks of gestation.
In hormone replacement therapy for perimenopausal and postmenopausal women, Susten 100mg is used in combination with oestrogen therapy to protect the endometrium from the proliferative effects of unopposed oestrogen, which carries a risk of endometrial hyperplasia and carcinoma. Bioidentical micronised progesterone is preferred over synthetic progestins in HRT for its more favourable safety profile — particularly regarding breast cancer risk, which is lower with micronised progesterone than with synthetic progestins in observational data. Susten 100mg is also used for secondary amenorrhoea (absence of menstrual periods), where a short course can induce withdrawal bleeding to confirm adequate oestrogen priming and assess the integrity of the endometrium and outflow tract.
Comparing Susten 100mg and Prometrium 100mg: Brand vs Generic Differences
Susten 100mg and Prometrium 100mg both contain progesterone 100mg and are prescribed for hormone imbalance, menstrual disorders, infertility support, and pregnancy-related progesterone supplementation. Prometrium is a branded progesterone medicine, while Susten is a generic alternative that is generally more affordable and widely available in India. Both medicines work in the same way by restoring progesterone levels in the body and are considered therapeutically similar when used as directed. However, they may differ in manufacturer, capsule shell composition, inactive ingredients, pricing, and packaging. Some patients may experience slight differences in absorption, digestion, or side effects such as drowsiness or bloating due to formulation variations. Doctors may choose one based on patient preference, cost, or availability. These medicines should always be used under proper medical supervision, especially during fertility or pregnancy treatment.
Related strengths and products: For women requiring higher progesterone doses — including those with inadequate implantation support or those in high-dose luteal support protocols — Susten 200mg provides double the progesterone content per capsule, reducing the daily capsule burden and enabling convenient dosing at 400 to 600mg daily where required.
Key Benefits of Susten 100mg
Susten 100mg delivers bioidentical micronised progesterone — molecularly identical to the body’s own progesterone — offering a more physiologically natural hormonal effect than synthetic progestins and a more favourable tolerability profile in terms of androgenic, metabolic, and cardiovascular side effects. Its dual route of administration flexibility — oral or vaginal — allows clinicians and patients to optimise delivery based on the clinical context: vaginal administration provides superior uterine tissue progesterone concentrations for ART luteal support, while oral administration is more convenient for HRT endometrial protection. The sedative properties of oral micronised progesterone (mediated by allopregnanolone) can be an advantage for women experiencing sleep disturbances around the perimenopause when used as an evening HRT dose. In ART, its role in enabling successful embryo implantation and supporting early pregnancy represents one of the most clinically significant applications of any pharmaceutical agent in reproductive medicine.
Usage warnings and precautionary advice for using Micronised Progesterone 100mg
Susten 100mg is contraindicated in patients with known or suspected progesterone-sensitive malignancies, undiagnosed vaginal bleeding, active thromboembolic disease or a history of progesterone-associated thromboembolism, and severe hepatic impairment. Patients with peanut or arachis oil allergy must not use the standard formulation. Progesterone therapy should be used with caution in patients with a history of depression — while micronised progesterone has a more favourable neuropsychiatric profile than synthetic progestins, mood effects can still occur in sensitive individuals. The sedative effect of oral micronised progesterone requires caution regarding driving and operating machinery within several hours of dosing — bedtime administration is strongly recommended to avoid daytime impairment. Progesterone affects glucose metabolism; diabetic patients should monitor blood glucose more closely during initiation of therapy. In ART protocols, the specific dose, route, timing, and duration of progesterone supplementation should be strictly adhered to as prescribed by the fertility specialist.
Side effects of Micronised Progesterone 100mg
Susten 100mg is generally well tolerated, particularly compared to synthetic progestins. The most commonly reported side effect of oral micronised progesterone is sedation and drowsiness, which occurs within 1 to 3 hours of oral dosing and is why evening or bedtime administration is routinely recommended. Dizziness and, in some women, euphoria or mood changes are occasionally noted. Breast tenderness is a common class effect of progestogen therapy and may occur during the progesterone phase of a cycle. Irregular spotting or breakthrough bleeding can occur, particularly during the initial months of HRT therapy. Vaginal administration is generally better tolerated systemically but may cause local effects, including vaginal discharge, irritation, or yeast overgrowth. Headache is occasionally reported. Thromboembolic events are a class concern for all sex hormone therapies, though observational data suggest micronised progesterone has a lower venous thromboembolism risk than many synthetic progestins.
Benefits of Buying Susten 100mg Online
AllDayChemist provides Susten 100mg at highly competitive prices with reliable international delivery — an important access channel for women undergoing IVF who require consistent and affordable progesterone supplementation across a treatment cycle, and for those on long-term HRT who benefit from the cost savings of ordering through AllDayChemist compared to local pharmacy pricing. Our discreet packaging and secure checkout help respect patient privacy in sensitive areas of women’s health.
Proper dosage and usage guide of Micronised Progesterone 100mg
For oral use, Susten 100mg capsules should be swallowed whole with water. For vaginal use, the capsule is inserted high into the vagina using a clean finger or an applicator, after which the patient should remain lying down for at least 30 minutes. For ART luteal phase support: typically 200 to 600mg daily vaginally (or orally as directed), starting on the day of embryo transfer and continuing for 8 to 12 weeks under physician guidance. For HRT endometrial protection: 100mg orally at bedtime for 12 to 14 consecutive days per month in a cyclic regimen with oestrogen, or as directed for continuous use. For secondary amenorrhoea: 100 to 200mg orally at bedtime for 10 to 12 days to induce a withdrawal bleed. Evening or bedtime administration of the oral dose is recommended to take advantage of progesterone’s sedative properties and minimise daytime drowsiness. Store below 25°C in a dry, dark place; avoid storage in warm or humid environments.
What is progesterone and what is it used for?
Progesterone is a natural hormone that plays a key role in women's reproductive health. Susten 100 mg contains progesterone and is used to treat several conditions including irregular periods, supporting early pregnancy, managing symptoms around menopause, and helping prepare the womb lining for pregnancy. It's especially helpful for women whose bodies don't make enough progesterone naturally. This hormone helps balance the effects of estrogen, another important female hormone, and keeps the menstrual cycle regular. Doctors also prescribe it to support fertility treatments and prevent problems during pregnancy.
How does progesterone actually work in the body?
Progesterone works by mimicking your body's own natural hormone. It attaches to special spots inside cells in your womb, ovaries, and breasts, sending signals that help regulate your menstrual cycle and prepare your womb for pregnancy. Think of it as creating a welcoming environment in the womb lining where a fertilized egg can attach and grow. It also calms the womb muscles to prevent early contractions during pregnancy. When used around menopause, progesterone balances estrogen to reduce symptoms like irregular bleeding. Essentially, it replaces or adds to the progesterone your body should be making naturally.
How long does Susten 100 mg take to start working?
The time Susten 100 mg takes to work varies depending on why you're taking it. For supporting early pregnancy or fertility treatments, it starts working within hours of taking it, though you may need to use it for weeks to see the full benefit. If you're using it for irregular periods, you might notice changes within one or two menstrual cycles. For menopause symptoms, some women feel relief within a few days, while others need several weeks of consistent use. The medicine enters your system quickly, but the visible improvements depend on your specific condition and how your body responds.
When and how should I take Susten 100 mg?
Take Susten 100 mg exactly as your doctor prescribes, as the timing depends on your specific condition. Some women take it once daily at bedtime, while others follow a schedule based on their menstrual cycle. It can be taken by mouth with water or inserted vaginally, depending on your doctor's instructions. Try to take it at the same time each day for best results. If you're using the vaginal route, lie down for a while afterward to help absorption. Always follow your prescribed schedule closely, as the timing is important for the medicine to work properly and achieve the results you need.
What should I do if I forget to take a dose of Susten 100 mg?
If you miss a dose of Susten 100 mg, take it as soon as you remember, unless it's almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular schedule. Never take two doses at once to make up for the one you forgot, as this can increase side effects. If you're using progesterone for fertility treatment or pregnancy support and miss a dose, contact your doctor for guidance since timing can be particularly important in these situations. Setting a daily alarm on your phone can help you remember to take it consistently.
Is it safe to take Susten 100 mg for a long time?
Many women safely use Susten 100 mg for extended periods when medically necessary, such as throughout pregnancy or during long-term hormone replacement therapy. The safety of long-term use depends on your individual health situation and why you need the medicine. Some women take it for just a few months, while others use it for years under medical supervision. Your doctor will regularly review whether you still need it and monitor for any potential issues. It's important to attend your scheduled checkups so your doctor can assess how the treatment is working and whether any adjustments are needed for your ongoing health and safety.
Can I take Susten 100 mg with other medicines I am already on?
Susten 100 mg can interact with certain medicines, so it's important to tell your doctor about everything you're taking, including over-the-counter medicines, vitamins, and herbal supplements. Some medicines that affect liver function, certain antibiotics, and epilepsy medicines may change how progesterone works in your body. Blood thinners, diabetes medicines, and other hormone treatments may also interact. However, many women safely combine Susten with other medicines once their doctor reviews their complete medication list and makes any necessary adjustments. Keep an updated list of all your medicines to share at every appointment for the safest treatment plan.
How is Susten 100 mg different from similar medicines used for the same condition?
Susten 100 mg contains natural progesterone that's identical to what your body produces, while some similar medicines contain synthetic versions called progestins. Natural progesterone like that in Susten is often preferred because it may have fewer side effects and works more like your body's own hormone. The 100 mg strength offers flexibility for different treatment needs and can be taken orally or used vaginally, giving you and your doctor options. Some other progesterone products come only in different strengths or different forms like creams or injections. The choice depends on your specific condition, how you prefer to take medicine, and how your body responds.
Is the generic version containing progesterone just as good as the branded medicine?
Yes, generic progesterone medicines like Susten 100 mg work just as effectively as branded versions because they contain the same active ingredient in the same strength. Generic medicines must meet strict quality standards and prove they work the same way in your body as the original branded product. The main differences are usually the name, packaging, and price, with generics typically costing less. Susten is a trusted generic option that delivers the same therapeutic benefits. Many doctors and patients choose generics to save money without sacrificing quality or effectiveness. The progesterone itself performs identically whether it's generic or branded.
What side effects can progesterone cause?
Progesterone commonly causes mild side effects like tiredness, dizziness, headaches, breast tenderness, bloating, and mood changes. Some women experience nausea, changes in appetite, or mild stomach discomfort. You might also notice changes in your menstrual bleeding pattern, especially when you first start taking it. Drowsiness is common, which is why many doctors recommend taking it at bedtime. Less common but more serious effects include severe allergic reactions, sudden vision changes, severe headaches, or unusual vaginal bleeding. Most side effects are mild and improve as your body adjusts. If you experience anything concerning or persistent, contact your doctor for advice.
Who should NOT take progesterone or needs to be extra careful with it?
Progesterone isn't suitable for everyone. You shouldn't use it if you have unexplained vaginal bleeding, certain types of cancer, blood clots, liver disease, or if you've had a stroke. Women with a history of depression, heart disease, kidney problems, diabetes, asthma, epilepsy, or migraines need extra monitoring while using progesterone. It's not safe during breastfeeding in some cases, and you must tell your doctor if you're pregnant or planning pregnancy, as the timing and reason for use matter. Anyone allergic to progesterone or peanuts (some formulations contain peanut oil) should avoid it. Always discuss your complete medical history before starting treatment.
Where can I buy Susten 100 mg online and be sure I am getting a genuine medicine?
Right here at AllDayChemist.com, we offer genuine Susten 100 mg sourced directly from trusted manufacturers. We've been serving patients in the USA, UK, Australia, and many other countries since 2002 as a licensed online pharmacy. We understand how important it is to receive authentic medicines, which is why we maintain strict quality standards and verify every product we supply. Our prices are competitive, and we ship discreetly worldwide with options for free shipping. Ordering is straightforward, and we make prescription management and reorders easy. When you buy from us, you're getting real medicine backed by nearly two decades of customer trust.
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