Available Dosages
| SKU: | 835 |
|---|---|
| Generic For: | Prometrium |
| Active Ingredient: | Progesterone |
| Manufacturer: | Sun Pharma, India |
Buy Susten 200mg (Progesterone) for Women's Health
Susten 200mg is a prescription oral softgel capsule containing Micronised Progesterone 200mg, the higher-strength formulation of bioidentical progesterone designed for clinical situations requiring greater progesterone exposure per dose. Susten 200mg is most commonly used in assisted reproductive technology (ART) protocols where high-dose luteal phase support is required, in the management of threatened miscarriage and preterm birth risk, and in hormone replacement therapy regimens where continuous-combined or higher-dose progestogen supplementation is prescribed. By delivering 200mg of bioidentical progesterone per capsule, Susten 200mg simplifies dosing for women who would otherwise need to take multiple 100mg capsules to reach therapeutic progesterone levels. This practical advantage directly supports treatment adherence in complex reproductive medicine protocols.
What is Susten 200mg?
Susten 200mg is an oral softgel capsule containing Micronised Progesterone 200mg dispersed in arachis oil or similar lipophilic excipient, available for both oral and vaginal administration. The 200mg strength is used when progesterone requirements exceed what the 100mg dose can conveniently provide within an acceptable daily number of capsules. In IVF luteal support protocols, where total daily vaginal progesterone doses of 400 to 600mg are standard, using 200mg capsules reduces the number of insertions or capsules required per day — from six 100mg to three 200mg for 600mg/day, for example — significantly reducing the practical burden of compliance. In threatened miscarriage management, 200 to 400mg daily of micronised progesterone is used to support the luteal-to-placental shift and maintain adequate uterine quiescence during the vulnerable first trimester. The same pharmacological properties and route flexibility as Susten 100mg apply, with the higher dose per unit providing greater dosing efficiency.
Manufacturer: Susten 200mg is manufactured by Sun Pharma (Sun Pharmaceutical Industries Ltd.), the leading Indian pharmaceutical company in women’s health and reproductive medicine, with extensive experience in micronised progesterone formulation technology under the established Susten brand.
Key Ingredients of Susten 200mg and Their Working Process
Micronised Progesterone 200mg delivers twice the progesterone content of the 100mg capsule within the same softgel vehicle. The mechanism of action of micronised progesterone at 200mg operates through the same progesterone receptor-mediated pathways as the 100mg dose, but achieves higher peak serum progesterone concentrations — typically two to three times higher than those produced by the 100mg oral dose — and sustains therapeutic progesterone levels for a longer period within the dosing interval. When administered vaginally, the 200mg dose produces substantially higher uterine tissue concentrations than oral administration of the same dose, due to the direct vaginal-uterine absorption pathway (the “first uterine pass effect”) that bypasses the dilution of systemic circulation. Uterine tissue progesterone concentrations after vaginal progesterone administration are several-fold higher than plasma concentrations, making vaginal administration particularly effective for endometrial preparation and support of embryo implantation.
At the serum and uterine concentrations achieved with 200mg dosing, progesterone receptor occupancy in the endometrium is more complete, ensuring thorough endometrial secretory transformation and maximal preparedness for embryo implantation. The neurosteroid metabolite allopregnanolone, produced in greater quantities from the 200mg dose, provides a correspondingly more pronounced sedative and anxiolytic effect — reinforcing the clinical recommendation to take the oral dose at bedtime. In myometrial tissue, progesterone at 200mg levels provides robust suppression of oxytocin-mediated and prostaglandin-mediated myometrial contractility — the pharmacological basis for its use in preventing preterm labour in at-risk pregnancies.
Clinical Uses of Micronised Progesterone 200mg
Susten 200mg is used across several distinct clinical applications where higher progesterone doses are required for therapeutic effect. In ART, 200mg administered vaginally twice or three times daily (400 to 600mg total) is the most common luteal phase support regimen — beginning on the day of oocyte retrieval or embryo transfer and continuing for 8 to 12 weeks until placental progesterone production is established. This regimen is the standard of care in IVF protocols worldwide, directly supporting embryo implantation and early pregnancy maintenance in cycles where the corpus luteum has been suppressed by GnRH agonist or antagonist protocols.
For threatened miscarriage — particularly in women with a history of recurrent early pregnancy loss where low progesterone is implicated — Susten 200mg used vaginally twice daily has been evaluated in clinical trials, including the PROMISE trial (which examined early pregnancy loss prevention) and the PRISM trial, where some benefit was found in women with prior miscarriage history and early bleeding. In preterm birth prevention, vaginal progesterone (200mg once nightly) from mid-pregnancy onwards reduces the risk of preterm delivery in women with a short cervix identified on midtrimester ultrasound — an application supported by multiple randomised trials and endorsed in international obstetric guidelines. In menopause, HRT, 200mg oral progesterone at bedtime is used in sequential regimens (12 to 14 days per cycle) for endometrial protection in women on oestrogen therapy.
Comparing Susten 200mg and Prometrium 200mg: Brand vs Generic Differences
Susten 200mg and Prometrium 200mg both contain the same active ingredient, progesterone 200mg, and are used to support pregnancy, manage hormonal imbalance, and treat progesterone deficiency. The main difference is that Prometrium is a well-known branded formulation, while Susten is considered a more affordable generic alternative available in many markets, including India. Both medicines work similarly by restoring progesterone levels, but they may differ in manufacturer, pricing, capsule composition, packaging, and inactive ingredients. Some patients may notice slight variations in absorption or tolerability, although their therapeutic effect is generally comparable when taken as prescribed. Doctors may recommend one over the other based on availability, cost, or patient response. Always use progesterone medicines under medical supervision, especially during pregnancy or fertility treatment.
Related strengths and products: Women beginning progesterone therapy or requiring lower doses for HRT endometrial protection may use Susten 100mg—the lower-strength capsule that provides more flexibility for initiating therapy or for sequential HRT regimens where the progesterone phase uses 100mg nightly. Susten 100mg and 200mg, or Susten 200/2ml (injection), can be used to achieve precise daily progesterone doses within ART protocols as,
Key Benefits of Susten 200mg
Susten 200mg provides a higher per-dose progesterone content, enabling clinically required high-dose luteal support regimens to be completed with a manageable number of capsules, directly supporting adherence in ART protocols where consistent progesterone supplementation is one of the most critical determinants of successful implantation and early pregnancy outcomes. Its bioidentical molecular structure ensures that receptor interactions, endometrial effects, and metabolic profile match those of natural progesterone — providing the most physiologically appropriate progestogen supplementation available for reproductive medicine applications. The dual oral and vaginal route flexibility allows clinical optimisation of delivery: vaginal use for maximum uterine concentrations in IVF, oral use for systemic HRT applications, or combined routes when both systemic and uterine effects are required. Sun Pharma’s Susten brand provides reliable progesterone quality and consistent capsule content at a price significantly below branded Utrogestan alternatives.
Usage warnings and precautionary advice for using Micronised Progesterone 200mg
All precautions applicable to Susten 100mg apply equally to the 200mg formulation, with greater clinical emphasis at the higher dose. Peanut allergy is a firm contraindication given the presence of arachis oil as an excipient. The sedative effects are more pronounced with 200mg than with 100mg — patients must be strongly advised against driving or operating machinery for several hours after oral administration. In ART protocols, progesterone must never be discontinued abruptly following a positive pregnancy test — the corpus luteum has been suppressed, and the conceptus is entirely dependent on supplemental progesterone until the placenta assumes production. Any interruption in therapy during this period carries a risk of pregnancy loss. Patients with a history of depression or mood disorders should be monitored for worsening symptoms, as the neurosteroid metabolites of progesterone can affect mood in both beneficial and occasionally adverse directions. Thromboembolic risk, while lower with micronised progesterone than with synthetic progestins, should be considered alongside other patient risk factors during pregnancy.
Side effects of Micronised Progesterone 200mg
At the 200mg dose, side effects are broadly similar to those of 100mg but may be somewhat more pronounced due to higher serum concentrations and greater neurosteroid metabolite production. Sedation and drowsiness are the most commonly reported effects with oral administration; dizziness and impaired concentration can occur in the hours following oral dosing, reinforcing the importance of bedtime administration. Breast tenderness and bloating are common progestogenic effects. Mood changes — ranging from mild anxiety or irritability to, in some women, improved mood and relaxation — reflect the complex neurosteroid pharmacology of progesterone metabolites. Vaginal administration typically produces fewer systemic sedative effects but causes local vaginal discharge (from capsule dissolution), which is expected and can be managed with a thin pantyliner. Vaginal irritation, fungal superinfection, or odour may occasionally occur with prolonged vaginal use. Headache and nausea are occasionally noted. In rare cases, allergic reactions to the arachis oil excipient can occur.
Benefits of Buying Susten 200mg Online
AllDayChemist offers Susten 200mg at highly competitive prices, with discreet international home delivery—a particularly valuable service for women undergoing IVF treatment who require consistent, affordable access to high-dose progesterone supplementation throughout their treatment cycle. The cost savings compared to branded Utrogestan 200mg are substantial and meaningful for patients who may undergo multiple ART cycles. AllDayChemist’s reliable supply chain and secure online platform ensure that critical medications arrive on schedule, without compromising on quality or privacy.
Proper dosage and usage guide of Micronised Progesterone 200mg
For oral administration, swallow Susten 200mg capsules whole with water, preferably at bedtime, to take advantage of the sedative effect and minimise daytime drowsiness. For vaginal administration, insert the capsule high into the vagina with a clean finger or applicator and remain recumbent for at least 30 to 60 minutes to facilitate dissolution and absorption. For IVF luteal support: typically 200mg vaginally two to three times daily (400 to 600mg total per day), starting from the day of oocyte retrieval or embryo transfer, as directed by the fertility clinic — do not alter the prescribed schedule without clinic guidance, as progesterone interruptions during this period can jeopardise implantation. For preterm birth prevention: 200mg vaginally once nightly from approximately 16 to 24 weeks of gestation until 36 weeks, as directed by the obstetrician. For threatened miscarriage: 200 to 400mg daily in divided doses vaginally, under obstetric supervision. For HRT: 200mg orally at bedtime for 12 to 14 days per cycle in sequential regimens. Store below 25°C away from direct light and heat.
What is progesterone and what is it used for?
Progesterone is a natural hormone that plays a key role in women's reproductive health. Susten 200mg contains this hormone and is used to treat several conditions including irregular or missed periods, difficulty getting pregnant, and supporting early pregnancy. It helps prepare the lining of the womb for pregnancy and keeps it healthy during the first weeks after conception. Doctors also prescribe it for women going through hormone replacement therapy during menopause, and to treat abnormal bleeding caused by hormone imbalances.
How does progesterone actually work in the body?
Progesterone works by mimicking the natural hormone your body makes after ovulation each month. It signals your womb lining to thicken and become rich with blood vessels, creating a welcoming environment for a fertilized egg. If you're pregnant, it keeps the womb lining stable and prevents contractions that might cause early pregnancy loss. When hormone levels are out of balance, Susten 200mg steps in to restore the natural rhythm your body needs, helping regulate your monthly cycle and reducing breakthrough bleeding.
How long does Susten 200mg take to start working?
The time Susten 200mg takes to work depends on why you're taking it. If you're using it to support early pregnancy or prevent miscarriage, it starts working within hours as hormone levels build up. For regulating periods or treating irregular bleeding, you might notice changes within one to two cycles, typically four to eight weeks. When used during fertility treatments, it begins preparing your womb lining immediately, though results depend on your overall treatment plan and individual response to the medicine.
When and how should I take Susten 200mg?
Take Susten 200mg exactly as your doctor prescribes, as timing varies based on your condition. It's usually taken once or twice daily, often at bedtime since it can cause drowsiness. You can take it with or without food, though taking it with food may reduce stomach upset. Some women use it vaginally rather than swallowing it, depending on their doctor's instructions. Always follow your prescribed schedule carefully, as timing matters for hormone treatments. Never adjust your dose without medical guidance, as hormone balance is delicate.
What should I do if I forget to take a dose of Susten 200mg?
If you miss a dose of Susten 200mg, take it as soon as you remember, unless it's almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular timing. Never take two doses at once to make up for a forgotten one, as this can cause unwanted effects. If you're using it for pregnancy support and miss a dose, don't panic but take it when you remember. Set phone reminders to help you stay on schedule.
Is it safe to take Susten 200mg for a long time?
Susten 200mg can be taken for extended periods when medically necessary, such as throughout early pregnancy or during ongoing hormone replacement therapy. Many women use it safely for months under medical supervision. However, long-term use requires regular check-ups to monitor your response and ensure it remains the right treatment for you. Your doctor will assess your individual situation, weighing the benefits against any potential risks based on your health history. Always attend follow-up appointments as scheduled so your treatment stays safe and effective.
Can I take Susten 200mg with other medicines I am already on?
Susten 200mg can interact with certain medicines, so it's important to tell your doctor about everything you take, including vitamins and herbal supplements. Some seizure medicines, antibiotics, and treatments for fungal infections may affect how progesterone works or how your body processes it. Blood thinners and some diabetes medicines might also interact. Keep a list of all your current medicines and share it during your consultation. Your doctor can adjust doses or timing if needed to keep all your treatments working properly and safely.
How is Susten 200mg different from similar medicines used for the same condition?
Susten 200mg contains natural progesterone that's identical to what your body produces, while some similar medicines contain synthetic versions called progestins. Natural progesterone often has fewer side effects and is considered gentler for many women, especially during pregnancy. The 200mg strength offers flexibility for various conditions, from cycle regulation to fertility support. Other progesterone products come in different forms like injections, gels, or vaginal inserts, but Susten capsules can be taken by mouth or used vaginally, giving you and your doctor treatment options.
Is the generic version containing progesterone just as good as the branded medicine?
Yes, generic progesterone medicines like Susten 200mg contain the same active ingredient in the same strength as branded versions and work identically in your body. They must meet the same strict quality standards and undergo rigorous testing before approval. The main difference is usually price, as generics cost significantly less while delivering the same therapeutic benefits. Many doctors actually prefer prescribing generics because they make treatment more affordable without sacrificing quality. Whether generic or branded, what matters most is consistent use as prescribed.
What side effects can progesterone cause?
Common side effects of progesterone include drowsiness, dizziness, headache, breast tenderness, and mood changes. Some women experience bloating, stomach upset, or changes in appetite. You might notice spotting or changes in your menstrual flow, especially when first starting treatment. Less commonly, progesterone can cause skin reactions, tiredness, or trouble sleeping. Most side effects are mild and improve as your body adjusts. If you experience severe headaches, sudden vision changes, chest pain, severe leg pain, or signs of an allergic reaction, seek medical attention immediately.
Who should NOT take progesterone or needs to be extra careful with it?
Progesterone isn't suitable for everyone. Avoid it if you have unexplained vaginal bleeding that hasn't been checked by a doctor, known or suspected breast cancer, blood clots or a history of them, liver disease, or if you've had a stroke or heart attack. Women with a history of depression, migraines, asthma, epilepsy, diabetes, or kidney problems need extra monitoring while taking it. Always tell your doctor if you're allergic to progesterone or similar hormones. Pregnant or breastfeeding women should only use it under medical supervision.
Where can I buy Susten 200mg online and be sure I am getting a genuine medicine?
You can buy authentic Susten 200mg directly from us at AllDayChemist.com, where we've been serving patients worldwide since 2002. We source every medicine directly from licensed manufacturers, ensuring you receive genuine products every time. As a fully licensed online pharmacy, we ship discreetly to the USA, UK, Australia, and many other countries, with competitive pricing and free shipping options available. We make reordering easy and handle prescription requirements professionally. Our reputation is built on delivering real medicines safely to your door, backed by over two decades of trusted service.
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